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Quantitative assessment of histopathology in NAFLD/NASH mouse model based on HALO digital pathology platform

 Last Update: 2022-08-30
 Source: Internet
 Author: User

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liver sinusoidal endothelial cells

lipid cell

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NAFLD/NASH

According to the diameter of lipid droplets in hepatocytes, hepatocyte steatosis can be divided into two types: microvesicular (microvesicular steatosis) and macrovesicular (macrovesicular steatosis), the former being the early stage of the latter.

Figure 1 Results of quantitative analysis of steatosis in the ROI of liver parenchyma

HALO Area Quantification can quantitatively analyze the area and percentage of collagen content in the liver parenchyma of the NASH mouse model (Masson's trichrome or PSR staining), and calculate the area and percentage of different PSR staining intensities according to the PSR staining intensity ( Figure 2)

In the entire tissue slide area, the total number of inflammatory cells and cell density were calculated

Figure 3 Quantitative analysis results of inflammatory cells in the ROI area of the liver parenchyma (the left and right images are before and after the quantitative analysis)

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