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Putting a "new weapon" on the oncolytic virus to treat pancreatic cancer shows a higher effect

 Last Update: 2021-10-02
 Source: Internet
 Author: User

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A few days ago, TILT Biotherapeutics announced that the oncolytic virus TILT-452 expressing IL-2 variants developed using the company’s oncolytic virus immunotherapy platform has achieved positive results in preclinical experiments

TILT-452 (named Ad5/3-E2F-d24-vIL2 in the paper) is an engineered 5/3 serotype chimeric adenovirus

▲The virus design structure of TILT-452 (picture source: reference [2])

In the pancreatic cancer hamster model, the tumors in the animals treated with TILT-452 shrank significantly, and at the end of the experiment (160 days later), 62.

▲TILT-452 treatment significantly reduces tumor volume and prolongs animal survival time (blue line, image source: reference [2])

TILT said that the company’s main oncolytic virus therapy TILT-123 built on TILT-452 is currently undergoing evaluation in phase 1 clinical trials

▲Design structure of TILT-123 oncolytic virus (picture source: TILT company official website)

TILT entered into a clinical cooperation agreement with Merck & Co.

Reference materials:

[1] TILT Biotherapeutics Reports Publication on its Oncolytic Immunotherapy Platform in Pancreatic Cancer.

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