Puerarin extract

Puerarin is extracted from radix puerariae, and its main dosage forms are tablets, injections, etc its main chemical component is saponin compound puerarin flavone, which has the functions of improving immunity, enhancing myocardial contractility, protecting myocardial cells, reducing blood pressure, anti platelet aggregation, etc [product name] puerarin [English name] puerarin [alias] puerarin, puerarin flavone, daidzein 8-c-glucoside [chemical name] 8-beta-d-glucopyranose-4 ', 7-dihydroxyisoflavone; 4, 7-dihydro-8 β - d-glucosylisoflavone [Formula] c21h20o9 [molecular weight] 416.38 [CAS NO] 3681-99-0 [source] is Pueraria lobata (wild.) Ohwi, P thunbergiana bench [Specification] 10% 20% 30% 40% 50%, 60% 80% 98% 99% [physical properties] brown powder with low content, white needle crystal powder with high content, MP 187 ℃ Dissolved in methanol, slightly soluble in ethanol, slightly soluble in water, insoluble in chloroform or ether If it's an injection, it's basically 99.5% or more, and related substances are required [pharmacological effect] 1 It contains saponins, which can protect the immune damage of liver tissue 2 It can effectively reverse chemical induced liver fibrosis 3 Enhance the contractility and protect the myocardial cells 4 It can dilate blood vessels, reduce blood pressure and improve microcirculation 5 Protect the deformability of red blood cells and enhance the function of hematopoietic system 6 It has the function of anti platelet aggregation, increasing fibrinolytic activity and reducing blood viscosity 7 It has protective effect on nephritis and renal failure model 8 It can regulate the nonspecific immunity, humoral immunity and cellular immunity 9 It can promote the lymphocyte transformation rate of normal people and tumor patients, and enhance the effect of natural element 10 It can stimulate and induce the interference system With the increase of dosage, the elimination half-life (Ti / 2) of the drug decreased to (11.80,10.37,4.6hr) and the distribution half-life increased to (0.53,0.64,0.67hr), which could pass through the blood-brain barrier The binding rate of plasma protein reached 24.60% Separately from urine Excretion of feces and bile It is widely distributed in the body, eliminated quickly, and is not easy to accumulate It has low toxicity and no obvious side effects The LD of Puerarin was 634.3mg/kg by intravenous injection and 1412.2mg/kg by intraperitoneal injection Puerarin (150100,50mg / kg) was injected intraperitoneally into rats for 5 weeks without any accumulative toxicity, and no obvious toxicity to heart, liver, lung, spleen, kidney, adrenal gland and intestine Puerarin was injected intravenously into dogs for 5 weeks, 50,30,15 mg / kg per day, and then observed for 70 days, which had no significant effect on stool routine, blood routine, SGPT, bun and blood glucose In the experiment of healthy adult SD rats, the dosage was 50150mg / kg, and there was no teratogenic effect on female rat embryo and male rat germ cells The mutagenicity test showed that puerarin had no potential carcinogenicity and mutagenicity Effects of Puerarin on liver system: Puerarin contains saponins, which has protective effect on immune damage of liver tissue C-29 hydroxyl group and C-5 "oxygen group can enhance liver protective activity Puerarin can protect liver injury, induce and activate apoptosis of hepatic stellate cells, effectively reverse chemical induced liver fibrosis, and protect acute liver injury induced by carbon tetrachloride Effects of Puerarin on cardiovascular system: Total Flavonoids in Pueraria can increase blood flow of brain and coronary artery Puerarin can promote brain circulation and peripheral circulation in animals and human body The total flavone of Pueraria lobata has a mild promoting effect on improving the cerebral vascular tension, elasticity and vasomotor supply of patients with hypertension and coronary heart disease Puerarin can not only improve the normal cerebral microcirculation, but also improve the microcirculation disturbance, which is mainly manifested in the increase of local microvascular blood flow and movement Puerarin can also improve the nail fold microcirculation of patients with sudden deafness, accelerate the blood flow speed of microvasculature, clear the blood stasis of vascular loop, and improve the hearing of patients Puerarin has a protective effect on hypoxic myocardium Puerarin can significantly reduce the oxygen consumption of ischemic myocardium and protect the heart from the ultrastructural damage caused by ischemia-reperfusion.