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Proteins that cause Alzheimer's disease may come from outside the brain

 Last Update: 2021-09-28
 Source: Internet
 Author: User

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Xinhua News Agency, Sydney, September 26 (Liu Shiyue) Australian researchers have discovered through animal experiments that the beta amyloid protein associated with Alzheimer's disease may come from other organs in the body and penetrate the brain through the blood

The lead author of the paper and an associate professor at Curtin University in Australia, Ryusuke Takeuchi, told Xinhua News Agency that the abnormal accumulation of amyloid β in the brain and the formation of plaques is one of the main pathogenic factors of Alzheimer’s disease, but this “toxic” The source of "protein" and the reason why it appears in the brain is still unclear

The researchers genetically modified the experimental mice so that the experimental mice produced beta amyloid, which is produced in humans, only in the liver instead of the brain

Takeuchi Ryusuke said that outside the brain, the liver and small intestine are the main organs that produce beta amyloid

He said that this research has brought new ideas for the prevention and treatment of Alzheimer's disease, such as adjusting the diet to maintain the balance of lipoproteins in the blood, or developing drugs that can block this permeation pathway

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