Proteins found in the blood to accurately diagnose liver fibrosis

Business Agency, May 11by by the Beijing Proteomics Research Center He Fuchu and Qian Xiaohong researcherled the research team, using quantitative proteomics, the overall systematic discovery of 72 high-confidence candidate proteins related to hepatic fibrosis classification in the plasma, for the clinical non-traumatic precision diagnosis of liver fibrosis provides an important basisThe results, published in China Science And Science Series: Life Sciences, were presented to the public at a recent meeting of the Chinese Association of Science and Technology Journals and the news medialiver fibrosis-cirrhosis-liver cancer, known as the "trilogy" of liver diseaseLiver fibrosis refers to the pathological process of abnormal growth of fibroblasts in the liver during necrosis and irritation by inflammation of liver cellsTimely and accurate diagnosis of liver fibrosis and early cirrhosis course of disease, the effective control of liver fibrosis is very importantAt present, liver fibrosis testing needs to be damaged and potentially dangerous by means of pathological puncture, and is not convenient for post-tracking and monitoring, thus limiting its clinical applicationAt present, some protein markers related to liver fibrosis and cirrhosis have been found in human plasma, but their sensitivity and accuracy can not meet clinical needs, and further exploration of plasma protein markers with clinical significance is requiredthe national "973" plan, the national science and technology major special funding, the research team using the quantitative proteomics based on stable isotope labeling technical analysis means, systematically analyzed the plasma protein sesame in the plasma related to the hepatic fibrosis grading process, found that in the 1109 obtained quantitative information of plasma protein, 72 of the liver fibrosis classification process significantly related to the "target" protein, constitute an important reference value, liver fiber classification index proteinThis provides important information for deepening understanding of the pathogenesis of liver fibrosis and clinically accurate diagnosis and treatment of liver fibrosisresearchers say the study also needs to expand validation and clinical evaluation in a large number of clinical sample populations and lay the foundation for the eventual acquisition of a "multi-marker compound precision diagnostic model."Extended readingChina is a high incidence of viral hepatitis, hepatitis B virus (HBV) alone carriers reached 120 million, of which there are more than 30 million patients with chronic hepatitis BGlobally, about 350 million people with chronic HBV infection, about 25% of patients with chronic hepatitis B will eventually develop cirrhosis and even liver cancerAccording to statistics, about 250,000 people die each year from liver failure, cirrhosis and liver cancer in the worldLiver disease is not incurable, liver fibrosis and cirrhosis can be controlled or cured, and the earlier the treatment effect is betterAs a result, Professor Hans Bober, founder of International Hepatology, has said that the vast majority of chronic liver disease can be cured by preventing or delaying the occurrence of liver fibrosis