Protective effect of Schisandra chinensis extract on liver injury in experimental hepatic fibrosis rats

Recently, researchers from the Department of pharmacology, School of pharmacy, Jilin University published a paper to observe the protective effect of Schisandra chinensis extract (efsc) on liver injury in experimental hepatic fibrosis rats and explore its mechanism The results show that efsc can improve the liver function, inhibit the formation of liver collagen fiber, correct the low level of Alb caused by liver fibrosis, alleviate the lipid peroxidation injury of liver cells, and prevent the formation and development of liver fibrosis This article was published in the 2nd issue of Journal of Jilin University (Medical Edition) in 2014 60 Wistar rats were randomly divided into control group, model group, mallotil group, 100, 200 and 400mg · kg-1 efsc group, 10 rats in each group CCl4 peanut oil solution was injected subcutaneously for 10 weeks to establish the rat model of experimental hepatic fibrosis The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), globulin (glo), total protein (TP) and nitric oxide (no) were measured four weeks after administration The activities of superoxide dismutase (SOD) and nitric oxide synthetase (NOS), malondialdehyde (MDA), glutathione (GSH) and hydroxyproline (Hyp) in liver tissue were measured Compared with the model group, the serum ALB level and ALB / glo ratio increased significantly (P < 0.05 or P < 0.01), the serum ast, ALT activity, glo and no level decreased significantly (P < 0.05 or P < 0.01), the liver SOD activity and GSH level increased significantly (P < 0.05 or P < 0.01), the Hyp and MDA level decreased significantly (P < 0.05).