Protective effect of chestnut extract on ccl_-induced acute liver injury in mice
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Last Update: 2014-08-12
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Source: Internet
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Author: User
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Recently, researchers from the pharmacy department of Gansu people's Hospital published a paper to investigate the protective effect of chestnut extract (EEHS) on CCl4 induced acute liver injury in mice The results showed that EEHS had a significant protective effect on ccl_-induced acute liver injury in mice This article was published in the Journal of Lanzhou University (Medical Edition), the first issue in 2014 Female Kunming mice were divided into 6 groups: normal control group, model control group, biphenyl diester group and chestnut seed extract low, medium and high dose group (75, 150 and 300mg / kg) The acute liver injury model of mice was established by CCl4 The activities of alt, AST, SOD, cat and GSH in serum and liver were measured Compared with the normal control group, the activity of alt, AST, cat in serum and cat in liver of the model control group were significantly increased (P < 0.01), while the activity of SOD and GSH in serum and liver were significantly decreased (P < 0.01); compared with the model control group, the activity of alt, AST, cat in serum and cat in liver of the model control group were significantly decreased (P < 0.01), and had concentration dependence; liver SOD activity and GSH content in tissue homogenate and serum increased significantly (P < 0.05).
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