Protective effect of buckwheat bran extract on myocardial injury in type 2 diabetic rats

Recently, researchers from the Department of pharmacology, School of basic medicine, Hebei Union University published a paper to explore the protective effect of buckwheat bran extract (EBC) on myocardial injury in type 2 diabetes mellitus (T2DM) rats and to elucidate its protective mechanism It is suggested that EBC can improve the cardiac morphology of T2DM rats, and its mechanism may be to improve the cardiac function by up regulating LVSP, HR and ± DP / dtmax and down regulating LVEDP This article was published in the Journal of Jilin University (Medical Edition), the 6th issue in 2013 The T2DM model of rats was established by feeding STZ with high sugar and fat Twenty three T2DM rats were divided into model control group (n = 8), EBC treatment group (n = 7) and benazepril treatment group (n = 8) Seven SD rats were taken as normal control group Rats in the EBC treatment group and benazepril treatment group were given EBC (200mg · kg-1 · D-1) and benazepril (4mg · kg-1 · D-1) by gavage; rats in the normal control group and model control group were given pure water (10ml · kg-1 · D-1) After 8 weeks of gavage, the body mass (BW), heart mass index (HWI), fasting blood glucose (FBG), left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), heart rate (HR) and the maximum rate of increase and decrease of left ventricular pressure (± DP / dtmax) were measured in each group, and the morphological changes of myocardial tissue were observed under light microscope Compared with the normal control group, FBG, HWI and LVEDP in the model control group increased (P < 0.01), BW, LVSP, HR and ± DP / dtmax decreased (P < 0.05 or P < 0.01); compared with the model control group, BW, LVSP, HR and ± DP / dtmax in the EBC treatment group and benazepril treatment group increased significantly (P < 0.05 or P < 0.01); while HWI, FBG and LVEDP decreased significantly (P < 0.05 or P < 0.01); EBC treatment group and benazepril The myocardial morphology of rats in the treatment group was improved.