Progress in research on new nano vaccine of Shenzhen Advanced Institute

Since the 21st century, nano vaccine research is one of the hot spots in life science research The vaccine carrier based on nano materials has brought great opportunities for the development of vaccine industry   Dr Ma Yifan, research group of Shenzhen Institute of advanced technology, Chinese Academy of Sciences, has been engaged in nano vaccine research for a long time Based on safe and degradable nano materials and innovative ideas, a new nano vaccine carrier based on seaweed polysaccharide was designed This kind of polysaccharide nanoparticles can not only deliver protein antigens to the immune system efficiently and safely, but also improve the level of specific antibodies and anti-tumor immune response by regulating the release process of antigens in cells This result provides an important strategy for the development of highly effective anti-tumor vaccine   In addition, the team also reported a nano vaccine carrier based on polypeptide polymer micelles This peptide nanoparticles not only simulate the structure of protein molecules, but also have many advantages, such as simple antigen loading method, high loading efficiency, good stability and so on It can activate a variety of immune cells, thus greatly improving the immune efficacy of the vaccine This research result provides a new opportunity for the development of highly efficient and safe adjuvant free vaccine, which is the first-class achievement of international nano vaccine research   Relevant achievements were published in the International Journal of controlled release recently   The above research has been supported by NSFC, key comprehensive strategic cooperation projects of Guangdong Academy of Sciences, Shenzhen basic research plan and other funds.