Progress in micro-environmental metabolic disorders outside macrophages

obesity,diabetes, cardiovascular disease and other metabolic diseases is the world's highest incidence and mortality of the diseaseMacrophages extracellular microenvironment signal disturbances, such as: inflammation, oxidative stress, nutrition, etc., can induce functional macrophages and other cells surrounding abnormal, thereby promotingdevelopment of metabolic diseasePrevious studies found that the major human food and oleic fatty acid may be exposed via inhibition of PPAR signaling induce macrophage lipid accumulation (CellDeath & Disease, 2019; JournalOfCellularAndMolecularMedicine, 2019)However, macrophage-related metabolic changes in the extracellular microenvironment extracellular remains unclearUrban EnvironmentMolecular Toxicology and Environmental Health Institute, Chinese Academy of group (Huang Mikio team) exposed application oleic acid-induced macrophage lipid accumulation extracellular microenvironment related metabolic disorders, and treated with resveratrol alcohol pioglitazone (
anti-diabetic drugs) interventionGC-MS metabolomic analysis showed that oleic acid exposure can induce significant changes in a number of metabolic pathways occur macrophages extracellular microenvironment, and said most of the variation can be mitigated or eliminated resveratrol alcohol pioglitazoneConcern is, most of oleic acid-induced exposure sugar, lactic acid, isoleucine, branched-chain amino acid metabolite, myristic acid and oleic acid in the extracellular microenvironment cells is significantly increased, whereas resveratrol may or pioglitazone effectively eliminating the extracellular microenvironment fructose, lactate, increased isoleucine and branched acid metabolitesThese results suggest that carbohydrate metabolism, glycolysis, fatty acid metabolism and amino acid metabolism may be branched as a metabolic diseaseresveratrol treatment and alcohol pioglitazone potential targets for interventionresearch to Metabolomiccharacterizationofmetabolicdisturbancesintheextracellularmicroenvironmentofoleate-treatedmacrophagesusinggaschromatography-massspectrometry was published in AnalyticalLetters, 2020Drurban environment leaves the country for the first injection and the corresponding author, DrMCH Jiangxi GENERALIZATION is co-corresponding authorThe study received national Zirankexue fund, fund Zirankexue Fujian, Jiangxi outstanding scientific and technological innovation team projects funded(A BiovalleyBioon.com)