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Professor Zhang Hongquan's team discovered a new molecular mechanism by which oxidative stress regulates the activation of Hippo signaling pathway and inhibits the growth of lung cancer cells

 Last Update: 2022-04-21
 Source: Internet
 Author: User

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On March 30, 2022, Professor Zhang Hongquan's team from Peking University School of Basic Medicine published a long research paper titled "Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway" in the journal Nucleic Acids Research, revealing that The role and molecular mechanism of oxidative stress regulating Hippo signaling pathway activation and inhibition of lung adenocarcinoma cell growth

Working model: Oxidative stress regulates Hippo signaling pathway activation through MOB1 acetylation and inhibits lung adenocarcinoma cell growth

The canonical Hippo signaling pathway is a series of kinase cascades, the major members of which in mammals include MST1/2, LATS1/2, SAV1, MOB1 and YAP/TAZ

Jin Jiaqi, a doctoral student at Peking University School of Basic Medicine, is the first author of the paper, and Professor Zhang Hongquan is the responsible author of the paper

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