Professor Yu Cao’s team published a paper in Circulation Research for the first time to reveal the effect of ischemic myocardial-derived extracellular microvesicles in inducing adipocyte dysfunction...

In December 2021, the team of Professor Yu Cao from the Emergency Department/Emergency Medicine Research Office of our hospital and the team of Professor Xinliang Ma and Professor Wang Yajing of Thomas Jefferson University from the United States published an online publication titled "Circulation Research (HX1, IF=17.

Cardiovascular disease (CVD) is one of the leading causes of death in the world

Emerging evidence supports the existence of a "heart-fat axis" in the human body

This study found that after 24 hours of cardiac ischemia/reperfusion (Myocardial ischemia/reperfusion, MI/R), adipose tissue endocrine-specific protein adiponectin (Adiponectin, APN) levels decreased, and endoplasmic reticulum (ER) function Changes in related protein expression

In summary, this study confirmed that after cardiac ischemia and reperfusion, the expression of miR-23-27-24 cluster in cardiomyocytes was significantly increased, and the cardiomyocyte-derived sEV was transported to adipocytes as a new signal carrier, inhibiting internal The expression of EDEM3, a key regulatory molecule in the degradation pathway of plasma reticulum proteins, promotes the unfolded protein response, leading to endoplasmic reticulum stress and endocrine dysfunction in adipocytes

The first author of this article is Gan Lu, an associate researcher of the Emergency Medicine Research Office of our hospital, and the corresponding authors are Professor Yu Cao of the Emergency Medicine/Emergency Medicine Research Office and Professor Wang Yajing of Thomas Jefferson University

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