Professor Liu Wen's team discovered the first specific small molecule inhibitor of the oxygenase JMJD6

Recently, the State Key Laboratory of Cell Stress Biology, Fujian Provincial Key Laboratory of Drug New Target Research, and Professor Liu Wen of the School of Pharmacy have found that the small molecule inhibitor iJMJD6 can specifically target the oxygenase JMJD6, inhibit the arginine demethylase activity of JMJD6, thereby effectively inhibiting the expression of oncogenes and the growth of various tumors such as breast cancer, liver cancer, cervical cancer, glioma and colorectal cancer, providing a potential and novel treatment for related cancers
。 The results were published online in the journal
PNAS under the title "A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo".

The JMJD6 protein containing the JmjC domain is a member
of the family of oxygenase enzymes dependent on metal ions and a-ketoglutaric acid.

Professor Liu Wen's team discovered iJMJD6, a small molecule inhibitor of JMJD6
, through large-scale screening.

Professor Wen Liu's team has long focused on the research of JMJD6 protein, and has achieved a series of high-level research results: it was revealed that JMJD6 and its interacting BRD4 protein remotely regulates the activity of the P-TEFb protein complex by binding to genomic enhancers relying on its demethylase activity, thereby regulating the transcriptional regulation novel model of transcriptional extension of adjacent coding genes (Cell.

Professor Liu Wen's team postdoctoral Xiao Rongquan is the first author of this paper, and Professor Liu Wen is the corresponding author
.

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