Pressure, poor ability! Cell reveals brown fat cell stress mechanism

Guide: "Good Fat" Plays a "Bad Role"?modern society, everyone's life under a lot of pressure, we all know that "stress mountain" will damage health, so that inflammatory diseases "make matters worse"However, how does stress reduce the body's resistance to disease and cause it to worsen? What is the relationship between stress and inflammation? In stressful environments, the body secretes hormones such as cortisol and adrenal, which should have weakened the inflammatory response, why under heavy pressure, inflammation is actually aggravated? These phenomena are still difficult for scientists to explainOn June 30,, Andrew Wang of Yale University School of Medicine published a research paper on Origin and Function of The Women's And Reed IL-6 in Murine Models in CellThe study revealed the origin and function of interleukin 6 (IL-6) in mice under pressure conditionsStudies have found that brown fat cells produce a large amount of IL-6 in stress responses, and THAT IL-6 is also associated with autoimmune diseases, cancer, obesity, diabetes, depression and anxietyspecifically, in order to study stress-induced immune media, the authors used a mouse stress model to screen 32 inflammatory fine D cytocytic factors and chemopting factors in the cycleThe results show that IL-6 is the most induced cytokine and can mediate long-lasting stress physiological effects (Figure D)IL-6 is produced from a variety of cell types, including hematopoietic cells, myocardial cells, endothelial cells, and fat cellsSo under pressure conditions, what cells are the increased IL-6 produced?to determine the source of IL-6, the authors used IL-6 defectmice to conduct a mixed bone marrow chimeric study and found that stress-induced IL-6 was not produced by radiation-sensitive cellsThe authors then used the hemorrhagic model to perform IL-6 induced screening of a variety of tissues and found that IL-6 was secreted by brown fat cells (Figure D)brown adipose tissue (BAT) plays an important role in energy metabolism and body temperature regulation, and the peripheral is directly controlled by sympathetic nervesThe authors speculate that IL-6 is induced by beta-adrenaline signalsTo test whether stress-induced IL-6 depends on sympathetic neurons, 6-hydroxydopamine (6-OHDA) is used to block the BAT sympathetic nerve without affecting the central nervous systemThe results showed that 6-OHDA post-treatment stress-induced IL-6 decreased significantly (Figure D) and was dependent on beta-adrenaline receptor 3 (Adrb3) (Figure E) considering that stress can produce a large number of IL-6s, the authors speculate that IL-6 has synergies with stress physiology Using indirect heat, the authors detected blocking the IL-6 signal, which resulted in a significant change in the total energy consumption of mice (Figure A) Moreover, IL-6 induces liver sugar in the course of stress, which increases the production of glucose in the body in subsequent experiments, the authors found that IL-6 increased mortality in endotoxin (LPS) inflammatory model mice and reduced the body's adaptability to LPS-induced inflammation Instead, by inhibiting IL-6 with the drug, the inflammatory response in mice can be inhibited, depression symptoms can be alleviated, etc overall, the study found that brown fat, when received a stress signal, secretes large amounts of IL-6 in a Dependent Form of Adrb3, which can trigger elevated blood sugar through liver sugar, which helps the body respond to a "fight or run away" response, but also causes inflammation brown fat cells not only "burn your calories", play a weight loss effect, but also regulate body temperature But in stressful environments, this fat cell can also exacerbate inflammation in the body Drugs for brown fat cells and IL-6 will help improve our ability to withstand stress and treat a variety of diseases References: Origin and Function of The Sty-Induc-6 in Murine Models