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Pressing on the "throat" of solid tumors, the results of preclinical experiments are surprising

 Last Update: 2021-09-13
 Source: Internet
 Author: User

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This discovery, published in the journal Science Advances, will help researchers develop new treatment strategies to limit the development of solid cancer tumors

Solid tumors rely on blood supply to deliver oxygen and nutrients to help them grow

To overcome this pressure, the cells adapt by releasing enzymes that neutralize the acidic environment, so that the cells not only survive, but eventually become a more aggressive tumor that can spread to other organs

"Cancer cells rely on the CAIX enzyme to survive, which ultimately makes it their'Achilles heel'

Previously, Dr.

In this study, the research team began to study these cell characteristics, and used a powerful tool, that is, the whole gene combination into a lethal screen to identify other weaknesses of the CAIX enzyme

According to Dr.

Dr.

Currently, a large-scale international effort is underway to identify drugs that can cause iron death

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