Preprint: Study from 25 countries: High coffee intake reduces stomach cancer risk

Introduction: Coffee is one of the second most popular beverages in the world, and it has antioxidant and anti-tumor propertiesStomach cancer is the fifth most common tumor in history and the second most fatal tumor in historyOn the relationship between coffee intake and the occurrence of stomach cancer, studies have been carried out by researchers to show that coffee intake has a significant correlation with the occurrence of stomach cancer, which may increase the risk of stomach cancerrecently, researchers at the University of Caliissi in Colombia published an article on preprinted website preprints, examining the association between coffee intake and stomach cancerThe results showed that coffee intake was negatively correlated with an increased risk of stomach cancerThis is a far cry from previous studiesThe most prominent ingredients in coffee are caffeine, coffee acid, chlorogenic acid, polyphenols, coffee alcohol and coffee white fat, which are known for their antioxidant and anti-tumor propertiesAntioxidants are substances that prevent, delay, or eliminate oxidative damage to target molecules, such as cells in carbohydrates, lipids, proteins, or nucleic acidsGastric cancer, on the other hand, is one of the top five most common malignancies in both men and women, ranking fifth after lung, breast, colorectal and prostate cancerIts annual mortality rate is high, with about 723,000 deaths a yearIts clinical manifestations are described as a multifactorial phenomenon, including factors such as age, Helicobacter pedestal seeding and eating habitsstudied the relationship between coffee intake and stomach cancer through prospective and retrospective epidemiological studies;because of the chemical composition of coffee drinks, it can be speculated that it plays an anti-tumor role in gastrointestinal diseases, especially stomach cancerIn this way, attention has begun to be paid to whether there is a relationship between coffee intake and the incidence and mortality of stomach cancer in the major intake countriesthe analysis, based on two separate sets of data on coffee consumption and cancer incidence, looked at the average annual coffee intake of people in 25 countriesa significant linear correlation between nationally estimated coffee intake and the incidence and mortality of stomach cancer the number of kilograms of coffee consumed per person per year and the estimated age-adjusted incidence of stomach cancer Sweden has the highest rates of stomach cancer and coffee intake The slope of the regression line is estimated to require approximately 7 kg of coffee per person per year in a given country to reduce the incidence of stomach cancer For Norway, this equates to 9.7 kg per year The lowest effective coffee dose seems to hover around 5-6 kg per year the relationship between annual coffee consumption and the standardized age incidence of stomach cancer in each country
there was also a significant linear correlation between the average annual coffee intake (kg) per capita and the estimated age-adjusted rate of stomach cancer mortality Sweden is also the best performer in terms of stomach cancer mortality and coffee intake The slope of the regression line can be estimated to require approximately 7 kg of coffee per person per year in a given country to reduce stomach cancer mortality the correlation between annual coffee intake and standardized mortality estimates for stomach cancer studies have some limitations The difference between coffee preparation methods (espresso, coffee or filtered coffee) and coffee seeds (Arabica coffee or Kanifula coffee) is not available for analysis, and considerable changes in the concentration of antioxidants and anti-tumor drugs depend on the preparation of the mixture However, one study assessed the ability of free radical scavengers and the protective effect softering of DNA by comparing 13 different coffee roasting methods It found that all preparations showed similar antioxidant activity, which could be explained by the presence of polyphenol extract sinfrom in all the beverages evaluated, which in turn affected antioxidant activity Furthermore, given the observed nature of the study, it cannot be directly concluded that the inverse relationship between coffee intake and the incidence or mortality of stomach cancer reflects causality Therefore, further research is needed to explain the causal relationship between them in general, coffee improves the bioavailability of gastrointestinal anti-tumor and antioxidants It may have potentially beneficial effects on the incidence and mortality of stomach cancer and is associated with morbidity and mortality in each analysed country