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Precise positioning of genes contributes to the correct positioning of the human heart

 Last Update: 2022-01-10
 Source: Internet
 Author: User

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From the outside, humans have a pleasing symmetry, with arms, legs, and eyes matching the left and right sides

But inside, it's another matter: our hearts are on the left;Our liver is on the right

Identify other genesThis breaks the initial symmetry of the developing round embryo and helps the organ choose sides

In 1998, based on studies in mice, Japanese researchers proposed that ciliated hair-like appendages rotating on a subset of tissue cells transport embryonic fluid to the left instead of the right.

Grimes said: "There are many puzzling results difficult to reconcile in the literature

Christopher Gordon of the Singapore Genome Institute and the Paris Institute of ImaginationI want to know whether this difference can suggest a way to find new genes that disrupt the symmetry of the human body

Five such genes, They are inNatural genetics.

SiropLike the organisers formed in zebrafish, mouse and frog embryos, it was turned on for several hours

So, Reversade and his team sortedSiropFrom 186 individuals with varying degrees of this so-called heterogeneity

SiropKyosuke Shinohara, a cell biologist at Tokyo University of Agriculture & Technology, said he was not involved in the work

SiropAbout how the asymmetry occurs

Emmanuelle Szenker Ravi of the Singapore Institute of Science, Technology and Research and colleagues are not clearSiropThe protein works and which proteins or genes it interacts with

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