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On June 10, a reporter from the Science and Technology Daily learned from Wuhan University that researchers from the Zhongnan Hospital of the school discovered that a lysosomal-related protein TMBIM1 has a key negative regulatory effect on adipogenesis and is a potential molecular target for the treatment of obesity-related metabolic disorders
.
The research was published online on June 8 in the top journal "Cell Metabolism" in the field of international metabolism
.
.
The research was published online on June 8 in the top journal "Cell Metabolism" in the field of international metabolism
.
With economic development and life>
.
At present, the treatment methods and methods used to treat or alleviate obesity and its metabolic disorders are still very limited
.
.
At present, the treatment methods and methods used to treat or alleviate obesity and its metabolic disorders are still very limited
.
Dr.
Zhao Guangnian from Zhongnan Hospital of Wuhan University, under the guidance of Professor Yuan Yufeng and Professor Li Hongliang, has confirmed through research that TMBIM1 is a brand-new factor that inhibits adipogenesis, plays a key negative regulatory role in adipogenesis and obesity-related metabolic disorders, and is a treatment for obesity-related metabolic disorders Potential molecular targets
.
Zhao Guangnian from Zhongnan Hospital of Wuhan University, under the guidance of Professor Yuan Yufeng and Professor Li Hongliang, has confirmed through research that TMBIM1 is a brand-new factor that inhibits adipogenesis, plays a key negative regulatory role in adipogenesis and obesity-related metabolic disorders, and is a treatment for obesity-related metabolic disorders Potential molecular targets
.
The study used bioinformatics methods to analyze the transcriptomics data of mouse and human preadipocyte differentiation, and found that TMBIM1 expression changes significantly during adipocyte differentiation.
The study confirmed that TMBIM1 played a role in inhibiting fat in the in vitro preadipocyte differentiation model.
The function of cell differentiation
.
In the high-fat diet-induced obesity model, the epididymal adipose tissue of the fat precursor cell-specific TMBIM1 knockout mice showed adipocyte hyperplasia, which improved the systemic metabolic disorders caused by obesity; and the fat precursor cell-specific TMBIM1 The epididymal adipose tissue of transgenic mice showed fat cell hypertrophy and its metabolic disorder was further deteriorated
.
The study confirmed that TMBIM1 played a role in inhibiting fat in the in vitro preadipocyte differentiation model.
The function of cell differentiation
.
In the high-fat diet-induced obesity model, the epididymal adipose tissue of the fat precursor cell-specific TMBIM1 knockout mice showed adipocyte hyperplasia, which improved the systemic metabolic disorders caused by obesity; and the fat precursor cell-specific TMBIM1 The epididymal adipose tissue of transgenic mice showed fat cell hypertrophy and its metabolic disorder was further deteriorated
.
The study revealed that the absence of TMBIM1 in adipose precursor cells can promote the hypertrophy of adipose tissue induced by overnutrition and improve the metabolic disorders caused by obesity.
It confirms the function and mechanism of TMBIM1 in adipogenesis and obesity-related metabolic disorders, and is used to treat obesity-related metabolism.
Disorders provide new molecular targets
.
( Technology Daily)
It confirms the function and mechanism of TMBIM1 in adipogenesis and obesity-related metabolic disorders, and is used to treat obesity-related metabolism.
Disorders provide new molecular targets
.
( Technology Daily)
On June 10, a reporter from the Science and Technology Daily learned from Wuhan University that researchers from the Zhongnan Hospital of the school discovered that a lysosomal-related protein TMBIM1 has a key negative regulatory effect on adipogenesis and is a potential molecular target for the treatment of obesity-related metabolic disorders
.
The research was published online on June 8 in the top journal "Cell Metabolism" in the field of international metabolism
.
.
The research was published online on June 8 in the top journal "Cell Metabolism" in the field of international metabolism
.
With economic development and life>
.
At present, the treatment methods and methods used to treat or alleviate obesity and its metabolic disorders are still very limited
.
.
At present, the treatment methods and methods used to treat or alleviate obesity and its metabolic disorders are still very limited
.
Dr.
Zhao Guangnian from Zhongnan Hospital of Wuhan University, under the guidance of Professor Yuan Yufeng and Professor Li Hongliang, has confirmed through research that TMBIM1 is a brand-new factor that inhibits adipogenesis, plays a key negative regulatory role in adipogenesis and obesity-related metabolic disorders, and is a treatment for obesity-related metabolic disorders Potential molecular targets
.
Zhao Guangnian from Zhongnan Hospital of Wuhan University, under the guidance of Professor Yuan Yufeng and Professor Li Hongliang, has confirmed through research that TMBIM1 is a brand-new factor that inhibits adipogenesis, plays a key negative regulatory role in adipogenesis and obesity-related metabolic disorders, and is a treatment for obesity-related metabolic disorders Potential molecular targets
.
The study used bioinformatics methods to analyze the transcriptomics data of mouse and human preadipocyte differentiation, and found that TMBIM1 expression changes significantly during adipocyte differentiation.
The study confirmed that TMBIM1 played a role in inhibiting fat in the in vitro preadipocyte differentiation model.
The function of cell differentiation
.
In the high-fat diet-induced obesity model, the epididymal adipose tissue of the fat precursor cell-specific TMBIM1 knockout mice showed adipocyte hyperplasia, which improved the systemic metabolic disorders caused by obesity; and the fat precursor cell-specific TMBIM1 The epididymal adipose tissue of transgenic mice showed fat cell hypertrophy and its metabolic disorder was further deteriorated
.
The study confirmed that TMBIM1 played a role in inhibiting fat in the in vitro preadipocyte differentiation model.
The function of cell differentiation
.
In the high-fat diet-induced obesity model, the epididymal adipose tissue of the fat precursor cell-specific TMBIM1 knockout mice showed adipocyte hyperplasia, which improved the systemic metabolic disorders caused by obesity; and the fat precursor cell-specific TMBIM1 The epididymal adipose tissue of transgenic mice showed fat cell hypertrophy and its metabolic disorder was further deteriorated
.
The study revealed that the absence of TMBIM1 in adipose precursor cells can promote the hypertrophy of adipose tissue induced by overnutrition and improve the metabolic disorders caused by obesity.
It confirms the function and mechanism of TMBIM1 in adipogenesis and obesity-related metabolic disorders, and is used to treat obesity-related metabolism.
Disorders provide new molecular targets
.
( Technology Daily)
It confirms the function and mechanism of TMBIM1 in adipogenesis and obesity-related metabolic disorders, and is used to treat obesity-related metabolism.
Disorders provide new molecular targets
.
( Technology Daily)
