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Figure: In order to induce antibodies to mainly target the structurally conserved regions in sars-related viruses in RBD, glycan engineering was carried out to mask the non-conserved dominant epitopes in the head region of RBD
Source: Ryo Shinnakasu et al
OSAKA, Japan-The COVID-19 pandemic caused by the β-coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reminds the world of the seriousness of the new virus threat
Coronavirus spike protein is a protein on the surface of SARS-CoV-2, which plays a vital role in attaching and entering host cells
The lead authors of the study, Ryo Shinnakasu and Shuhei Sakakibara, explained: “The key to making a vaccine that can provide broad cross-protection among related viruses is to target highly conserved structures on the surface of the virus
This discovery is particularly promising because it demonstrates the potential of highly protective vaccines against various sars-related viruses
The new methods of vaccine design they describe may help prevent future global health crises, such as those experienced during the COVID-19 pandemic
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This article titled "Glycan engineering of the SARS-CoV-2 receptor binding domain triggers cross-neutralizing antibodies to sars-related viruses" was published in DOI: https://doi.
Magazine
Journal of Experimental Medicine
DOI
10.
Methodological research
Experimental Study
Subject of research
animal
Article title
Glycan engineering of the SARS-CoV-2 receptor binding region leads to cross-neutralizing antibodies against sars-related viruses
Article publication date
8-October-2021
COI statement
N.
