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Potential genes that affect the severity of brain development

 Last Update: 2021-09-20
 Source: Internet
 Author: User

Disease genes restore SHH pathway

For a long time, researchers have believed that there are some genes that will have a positive effect on this deformity, or even prevent it completely

But this result is partly due to chance

High-throughput sequencing RNA analysis

In order to do this, Mecklenburg first bred different mouse strains and examined the animal's disease characteristics, signal pathways and genetic makeup

The researchers conducted further studies and found that in the white LRP2 mutant and the wild type of the strain, certain genes, including ULK4 and PTTG1, were significantly up-regulated compared with black 6 mice

Decoding—maybe even preventing—genetic diseases

Hammes said: "We have identified these candidate genes that modulate the SHH pathway in mice.

DOI

https://doi.

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