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When the "strongest brain" meets the "strongest computing power", what kind of sparks will collide?
As a post-80s doctoral tutor at West China Clinical School of Medicine, Sichuan University, Tian Xiaohe's team is working on Alzheimer's disease researc.
"The results of the experimental data are very good, and almost all physical lesions have been remove.
Joined forces
Join hands with the "strongest computing power" in Southwest China
Looking for a brain "passport"
Alzheimer's disease (AD), also known as Alzheimer's disease, is a progressive neurodegenerative disease with insidious onse.
At present, drugs for the treatment of Alzheimer's generally face a problem, that is, drugs cannot precisely act on the brain through the "barrier.
The brain has 100 billion cells, and it is very difficult for drugs to "camouflage" successfull.
To put it simply, they need to select tens of thousands of parameters, and then design complex formulas, which may involve hundreds of millions of permutation and combination workloads, select the optimal formula from them, and design drugs with "passports.
In 2020, by chance, Tian Xiaohe learned about the Chengdu Supercomputing Cente.
The highest computing speed of Chengdu Supercomputing Center reaches 1 billion times per second, ranking among the top ten in the world in computing speed, which is equivalent to the computing power of 5 million 8-core home computers, and the computing speed per second is equivalent to that of 2 billion people in the world using calculators at the same tim.
"At present, we are close to finding the best formula for designing drug.
Experimental results
Physical lesions almost disappeared
Preparing to apply for a preclinical trial
Alzheimer's disease is like an eraser in the head, slowly and painfully erasing a person's memory and cognition, and eventually the patient will forget everything stored in the brain and completely lose the ability to take care of themselve.
According to public information, in the face of a huge number of patients, in the past 20 years, pharmaceutical companies' research in the field of new AD drugs has almost been wiped out, and most of the new drugs have "fallen" in clinical trial.
Tian Xiaohe said that there has been a lot of debate in the scientific research community about the cause of Alzheimer's disease, but the statement that Aβ deposition in the brain leads to the fibrillary tangles of Tau protein and finally leads to the death of nerve cells has been accepted by the medical communit.
"From the imaging point of view, almost all physical lesions have been removed, but there is still a long way to go to improve cognition and apply it to the clini.
12 years of research
Phased progress of the project
He always motivates himself to work hard
The reporter first met Tian Xiaohe in the Science and Technology Park of West China Hospital of Sichuan Universit.
In 2010, Tian Xiaohe went to the School of Engineering and Materials and the School of Biomedical Sciences at the University of Sheffield to study for a master's and a doctorate, during which time he began to get in touch with research related to the central nervous syste.
West China Metropolis Daily - Cover reporter Liu Qiufeng
