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    Home > Biochemistry News > Biotechnology News > PNAS|Jiang Zhengfan's laboratory and collaborators reveal the important role of manganese ions in anti-bacterial innate immunity

    PNAS|Jiang Zhengfan's laboratory and collaborators reveal the important role of manganese ions in anti-bacterial innate immunity

    • Last Update: 2021-10-22
    • Source: Internet
    • Author: User
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    On October 9, 2021, the Jiang Zhengfan Laboratory of the Academy of Biological Sciences and the Shen Xihui Laboratory of the Northwest University of Agriculture and Forestry and the Zhou Dongsheng Laboratory of the Military Medical College jointly published their online anti-bacterial natural immunity in the internationally renowned academic journal "PNAS" in the form of Research Article The latest achievement in the research field-T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese


    Natural immunity senses pathogen invasion through pattern recognition receptors and activates downstream responses to resist pathogen infection


    The bacterial type VI secretion system (T6SS, type VI secretion system) is one of the current research hotspots in the field of microbes.


    This study found that the gram-negative bacterium Y.



    TssS chelates manganese ions to inhibit STING- mediated anti-bacterial natural immune response in host cells

    Unlike other known bacterial effectors that usually cause disease by interacting with host intracellular proteins, nucleic acids and other macromolecules, this study reveals that a bacterial effector protein can inhibit the host's natural immunity by chelating manganese ions in the host cell.


    Postdoctoral fellows Zhu Lingfang and Xu Lei of Northwest University of Agriculture and Forestry Science and Technology, and postdoctoral fellow of Peking University School of Biological Sciences Wang Chenguang are the co-first authors of this paper.


    Original link: https://doi.


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