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Recently, the team of Prof.
Bingqiao Zhao from the Institute of Brain Science of Fudan University/State Key Laboratory of Medical Neurobiology published a research paper titled "The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice" online in the Proceedings of the National Academy of Sciences "PNAS".
, revealing the important role of the small molecule drug "MLN4924" in regulating neurovascular injury in stroke
.
Stroke, also known as "cerebral apoplexy", is the leading cause of death and disability among adults in China
.
The NEDD8 activating enzyme inhibitor "MLN4924" is a small molecule anticancer drug developed in recent years
.
Zhao Bingqiao's team found that ischemic stroke caused the abnormal activation of NEDD8-like ubiquitination pathway in neutrophils, and "MLN4924" caused the aggregation of substrate protein NF1 by inactivating cullin-RING E3 ubiquitin ligase, and then Inhibit neutrophil vascular extravasation, repair damaged blood-brain barrier, reduce brain damage and improve neurological function
.
This study revealed the potential effect of "MLN4924" on ischemic stroke, and provided a novel strategy for the treatment of stroke
.
Figure: Stroke-induced abnormal activation of the ubiquitin-like protein NEDD8 in neutrophils inside and outside the blood vessels This study was supported by the National Natural Science Foundation of China and the Key R&D Program of the Ministry of Science and Technology
.
Yu Huilin, Luo Haiyu, Chang Luping, and Wang Shisheng of West China Hospital of Sichuan University are the co-first authors of the paper; Professor Zhao Bingqiao of Fudan University, Researcher Fan Wenying and Associate Researcher Yang Hao of West China Hospital are the co-corresponding authors of the paper
.
Paper link: https://iobs.
fudan.
edu.
cn/_upload/article/files/d5/bb/0d21dad9496b9843c180aabd6d31/8f6382bd-32ff-4300-ac6a-7f3800d2d4a9.
pdf
Bingqiao Zhao from the Institute of Brain Science of Fudan University/State Key Laboratory of Medical Neurobiology published a research paper titled "The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice" online in the Proceedings of the National Academy of Sciences "PNAS".
, revealing the important role of the small molecule drug "MLN4924" in regulating neurovascular injury in stroke
.
Stroke, also known as "cerebral apoplexy", is the leading cause of death and disability among adults in China
.
The NEDD8 activating enzyme inhibitor "MLN4924" is a small molecule anticancer drug developed in recent years
.
Zhao Bingqiao's team found that ischemic stroke caused the abnormal activation of NEDD8-like ubiquitination pathway in neutrophils, and "MLN4924" caused the aggregation of substrate protein NF1 by inactivating cullin-RING E3 ubiquitin ligase, and then Inhibit neutrophil vascular extravasation, repair damaged blood-brain barrier, reduce brain damage and improve neurological function
.
This study revealed the potential effect of "MLN4924" on ischemic stroke, and provided a novel strategy for the treatment of stroke
.
Figure: Stroke-induced abnormal activation of the ubiquitin-like protein NEDD8 in neutrophils inside and outside the blood vessels This study was supported by the National Natural Science Foundation of China and the Key R&D Program of the Ministry of Science and Technology
.
Yu Huilin, Luo Haiyu, Chang Luping, and Wang Shisheng of West China Hospital of Sichuan University are the co-first authors of the paper; Professor Zhao Bingqiao of Fudan University, Researcher Fan Wenying and Associate Researcher Yang Hao of West China Hospital are the co-corresponding authors of the paper
.
Paper link: https://iobs.
fudan.
edu.
cn/_upload/article/files/d5/bb/0d21dad9496b9843c180aabd6d31/8f6382bd-32ff-4300-ac6a-7f3800d2d4a9.
