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March 19, 2021---According to a recent study, researchers found previously unknown hepatitis B virus in donkeys and zebras, providing new opportunities to understand the course of the disease.
The research was led by DZIF scientists at Charité and Justus Liebig University Giessen in Berlin.
March 19, 2021---According to a recent study, researchers found previously unknown hepatitis B virus in donkeys and zebras, providing new opportunities to understand the course of the disease.The research was led by DZIF scientists at Charité and Justus Liebig University Giessen in Berlin.
The research was led by DZIF scientists at Charité and Justus Liebig University Giessen in Berlin.
(Image source: www.
pixabay.
com)
pixabay.
com)
Hepatitis B virus (HBV) infection is a major global health problem.
It is particularly troublesome that the chronic course of the disease is very long, causing more than 800,000 deaths worldwide every year.
So far, there is no cure for this disease.
"With the discovery of a new type of hepatitis B virus that can cause long-term infections in donkeys and zebras, we now have the opportunity to better understand the chronic course of the disease, thereby reducing or preventing serious clinical consequences," Charité-Berlin Said Professor Jan Felix Drexler, DZIF researcher at the University Medical Department.
At the German Research Center for Infections (DZIF), he identified and identified emerging viruses that may pose a danger to humans.
It is particularly troublesome that the chronic course of the disease is very long, causing more than 800,000 deaths worldwide every year.
So far, there is no cure for this disease.
"With the discovery of a new type of hepatitis B virus that can cause long-term infections in donkeys and zebras, we now have the opportunity to better understand the chronic course of the disease, thereby reducing or preventing serious clinical consequences," Charité-Berlin Said Professor Jan Felix Drexler, DZIF researcher at the University Medical Department.
At the German Research Center for Infections (DZIF), he identified and identified emerging viruses that may pose a danger to humans.
The lead author of the study, DZIF scientist Andrea Rasche of the Berlin Philanthropy University, explained: “Five years ago, we showed for the first time the virus related to human hepatitis C virus genes carried by donkeys.
” Because of HBV and hepatitis C virus (HCV) ) Usually occurs simultaneously in humans, so researchers are also searching for HBV in donkeys around the world.
In addition to field work, a wide range of molecular, serological, histopathological and evolutionary biology methods are also used.
Drexler explained: "We have studied nearly 3,000 animal samples from donkeys, zebras and horses from five continents, and we have found that donkeys are global carriers of the new hepatitis B virus.
"
” Because of HBV and hepatitis C virus (HCV) ) Usually occurs simultaneously in humans, so researchers are also searching for HBV in donkeys around the world.
In addition to field work, a wide range of molecular, serological, histopathological and evolutionary biology methods are also used.
Drexler explained: "We have studied nearly 3,000 animal samples from donkeys, zebras and horses from five continents, and we have found that donkeys are global carriers of the new hepatitis B virus.
"
The origin of the new HBV may be related to the domestication of African donkeys thousands of years ago.
Donkeys are infected with HBV and HCV under natural conditions.
Zebras are also infected with hepatitis B virus.
Scientists speculate that horses may also be infected, but in preliminary studies, scientists were unable to identify any naturally infected horses.
In naturally infected donkeys, the course of infection is similar to human chronic hepatitis B.
Donkeys are infected with HBV and HCV under natural conditions.
Zebras are also infected with hepatitis B virus.
Scientists speculate that horses may also be infected, but in preliminary studies, scientists were unable to identify any naturally infected horses.
In naturally infected donkeys, the course of infection is similar to human chronic hepatitis B.
The second author of the study, scientist Felix Lehmann of the University of Giessen, explained: “The new hepatitis B virus seems to use an unknown receptor to enter the host cell.
” He studied the molecular biology of virus binding and entry in cell culture.
It is unclear about the emergence of human HBV and the development of its receptor use.
Researchers in Berlin and Giessen jointly investigated it.
” He studied the molecular biology of virus binding and entry in cell culture.
It is unclear about the emergence of human HBV and the development of its receptor use.
Researchers in Berlin and Giessen jointly investigated it.
"Because the virus cannot infect human liver cells, the possibility of human infection with the virus can be highly ruled out," emphasized Dr.
Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
Information source: com/news/2021-03-hepatitis-people-donkeys.
html" >Hepatitis B: What people can learn from donkeys
html" >Hepatitis B: What people can learn from donkeys
Original source: Andrea Rasche et al, A hepatitis B virus causes chronic infections in equids worldwide, Proceedings of the National Academy of Sciences (2021).
DOI: 10.
1073/pnas.
2013982118
DOI: 10.
1073/pnas.
2013982118
(Image source: www.
pixabay.
com)
pixabay.
com)
Hepatitis B virus (HBV) infection is a major global health problem.
It is particularly troublesome that the chronic course of the disease is very long, causing more than 800,000 deaths worldwide every year.
So far, there is no cure for this disease.
"With the discovery of a new type of hepatitis B virus that can cause long-term infections in donkeys and zebras, we now have the opportunity to better understand the chronic course of the disease, thereby reducing or preventing serious clinical consequences," Charité-Berlin Said Professor Jan Felix Drexler, DZIF researcher at the University Medical Department.
At the German Research Center for Infections (DZIF), he identified and identified emerging viruses that may pose a danger to humans.
Hepatitis B virus (HBV) infection is a major global health problem. It is particularly troublesome that the chronic course of the disease is very long, causing more than 800,000 deaths worldwide every year.
So far, there is no cure for this disease.
"With the discovery of a new type of hepatitis B virus that can cause long-term infections in donkeys and zebras, we now have the opportunity to better understand the chronic course of the disease, thereby reducing or preventing serious clinical consequences," Charité-Berlin Said Professor Jan Felix Drexler, DZIF researcher at the University Medical Department.
At the German Research Center for Infections (DZIF), he identified and identified emerging viruses that may pose a danger to humans.
It is particularly troublesome that the chronic course of the disease is very long, causing more than 800,000 deaths worldwide every year.
So far, there is no cure for this disease.
"With the discovery of a new type of hepatitis B virus that can cause long-term infections in donkeys and zebras, we now have the opportunity to better understand the chronic course of the disease, thereby reducing or preventing serious clinical consequences," Charité-Berlin Said Professor Jan Felix Drexler, DZIF researcher at the University Medical Department.
At the German Research Center for Infections (DZIF), he identified and identified emerging viruses that may pose a danger to humans.
The lead author of the study, DZIF scientist Andrea Rasche of the Berlin Philanthropy University, explained: “Five years ago, we showed for the first time the virus related to human hepatitis C virus genes carried by donkeys.
” Because of HBV and hepatitis C virus (HCV) ) Usually occurs simultaneously in humans, so researchers are also searching for HBV in donkeys around the world.
In addition to field work, a wide range of molecular, serological, histopathological and evolutionary biology methods are also used.
Drexler explained: "We have studied nearly 3,000 animal samples from donkeys, zebras and horses from five continents, and we have found that donkeys are global carriers of the new hepatitis B virus.
"
The lead author of the study, DZIF scientist Andrea Rasche of the Berlin Philanthropy University, explained: “Five years ago, we showed for the first time the virus related to human hepatitis C virus genes carried by donkeys. ” Because of HBV and hepatitis C virus (HCV) ) Usually occurs simultaneously in humans, so researchers are also searching for HBV in donkeys around the world.
In addition to field work, a wide range of molecular, serological, histopathological and evolutionary biology methods are also used.
Drexler explained: "We have studied nearly 3,000 animal samples from donkeys, zebras and horses from five continents, and we have found that donkeys are global carriers of the new hepatitis B virus.
"
” Because of HBV and hepatitis C virus (HCV) ) Usually occurs simultaneously in humans, so researchers are also searching for HBV in donkeys around the world.
In addition to field work, a wide range of molecular, serological, histopathological and evolutionary biology methods are also used.
Drexler explained: "We have studied nearly 3,000 animal samples from donkeys, zebras and horses from five continents, and we have found that donkeys are global carriers of the new hepatitis B virus.
"
The origin of the new HBV may be related to the domestication of African donkeys thousands of years ago.
Donkeys are infected with HBV and HCV under natural conditions.
Zebras are also infected with hepatitis B virus.
Scientists speculate that horses may also be infected, but in preliminary studies, scientists were unable to identify any naturally infected horses.
In naturally infected donkeys, the course of infection is similar to human chronic hepatitis B.
The origin of the new HBV may be related to the domestication of African donkeys thousands of years ago. Donkeys are infected with HBV and HCV under natural conditions.
Zebras are also infected with hepatitis B virus.
Scientists speculate that horses may also be infected, but in preliminary studies, scientists were unable to identify any naturally infected horses.
In naturally infected donkeys, the course of infection is similar to human chronic hepatitis B.
Donkeys are infected with HBV and HCV under natural conditions.
Zebras are also infected with hepatitis B virus.
Scientists speculate that horses may also be infected, but in preliminary studies, scientists were unable to identify any naturally infected horses.
In naturally infected donkeys, the course of infection is similar to human chronic hepatitis B.
The second author of the study, scientist Felix Lehmann of the University of Giessen, explained: “The new hepatitis B virus seems to use an unknown receptor to enter the host cell.
” He studied the molecular biology of virus binding and entry in cell culture.
It is unclear about the emergence of human HBV and the development of its receptor use.
Researchers in Berlin and Giessen jointly investigated it.
The second author of the study, scientist Felix Lehmann of the University of Giessen, explained: “The new hepatitis B virus seems to use an unknown receptor to enter the host cell. ” He studied the molecular biology of virus binding and entry in cell culture.
It is unclear about the emergence of human HBV and the development of its receptor use.
Researchers in Berlin and Giessen jointly investigated it.
” He studied the molecular biology of virus binding and entry in cell culture.
It is unclear about the emergence of human HBV and the development of its receptor use.
Researchers in Berlin and Giessen jointly investigated it.
"Because the virus cannot infect human liver cells, the possibility of human infection with the virus can be highly ruled out," emphasized Dr.
Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
Information source: com/news/2021-03-hepatitis-people-donkeys.
html" >Hepatitis B: What people can learn from donkeys
html" >Hepatitis B: What people can learn from donkeys
"Because the virus cannot infect human liver cells, the possibility of human infection with the virus can be highly ruled out," emphasized Dr.
Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
"Because the virus cannot infect human liver cells, the possibility of human infection with the virus can be highly ruled out," emphasized Dr. Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
Dieter Glebe, head of the National Reference Center for Hepatitis B and D Virus in the United States.
The authors firmly believe that by infecting the virus in donkeys and zebras, they can better understand the pathogenesis of chronic hepatitis B and HBV/HCV co-infection, thereby laying the foundation for new therapies.
(Bioon.
com)
Information source: com/news/2021-03-hepatitis-people-donkeys.
html" >Hepatitis B: What people can learn from donkeys
html" >Hepatitis B: What people can learn from donkeys
Information source: com/news/2021-03-hepatitis-people-donkeys.
html" >Hepatitis B: What people can learn from donkeys
Information source: com/news/2021-03-hepatitis-people-donkeys. html" >Hepatitis B: What people can learn from donkeys
html" >Hepatitis B: What people can learn from donkeys
Original source: Andrea Rasche et al, A hepatitis B virus causes chronic infections in equids worldwide, Proceedings of the National Academy of Sciences (2021).
DOI: 10.
1073/pnas.
2013982118
DOI: 10.
1073/pnas.
2013982118
Original source: Andrea Rasche et al, A hepatitis B virus causes chronic infections in equids worldwide, Proceedings of the National Academy of Sciences (2021).
DOI: 10.
1073/pnas.
2013982118
DOI: 10.
1073/pnas.
2013982118
Original source: Andrea Rasche et al, A hepatitis B virus causes chronic infections in equids worldwide, Proceedings of the National Academy of Sciences (2021).
DOI: 10.
1073/pnas.
2013982118
Original source: Andrea Rasche et al, A hepatitis B virus causes chronic infections in equids worldwide, Proceedings of the National Academy of Sciences (2021). DOI: 10.
1073/pnas.
2013982118
DOI: 10.
1073/pnas.
2013982118
