PNAS: Seasonal changes in antioxidant pathways regulate winter depression-like behavior
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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Seasonal changes in the environment can lead to depression-like behavior in humans and animalsTo date, however, its basic mechanism sits unclearrecently, researchers have observed a decrease in the social ability of herring exposed to a winter-like environment and an increase in anxiety-like behaviorWhole-brain myomics analysis found seasonal changes in 68 metabolites, including neurotransmitters and antioxidants associated with depressionTranscriptional group analysis found 3,306 transcripts of different expressions, including inflammatory markers, melanin proteins, and circadian rhythm genesfurther analysis found seasonal changes in various signaling pathways in depression, including the antioxidant pathways of nuclear factor red blood cell derivatives -2 (NRF2)a broad-spectrum chemical screening found that Serrastero, a chinese medicine, can uniquely reverse winter behaviorNRF2 is an celastrol target expressed in the meninges of the brain (HB) and is known to play a key role in the pathophysiology of depressionAnother NRF2 chemical activator showed a similar effect, while the NRF2 mutants showed decreased social abilitytherefore, this study provides important insights into winter depression and provides potential therapeutic targets for NRF2
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