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The team believes that astrocytes are closely related to the death of motor neurons
"We think this is very important because astrocyte dysfunction is active after ALS patients develop symptoms," said Nicholas Malagakis, MD, PhD, Johns Hopkins Medicine Professor of Neurology and Medical Director of the Johns Hopkins ALS Clinical Trials Unit
In the study, published March 21 in PNAS, the researchers analyzed brain and spinal cord tissue from ALS patients and observed that a specific astrocyte protein, connexin 43, acts as an open pore that sends toxic factors from astrocytes to motor neurons
The research team was also able to grow stem cell lines from ALS patients and grow them into astrocytes
Malagakis said: "This is a new pathway that we have shown to exist in ALS tissue, animal models and patient-derived stem cells
Malagakis said drugs are being developed that can block this hemichannel
Malagakis said the study provides growing evidence that astrocytes play a role in the spread of ALS
Akshata A.
