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The study, "Single-dose ethanol intoxication causes acute and long-lasting neuronal changes in the brain," was published in the Proceedings of the National Academy of Sciences (PNAS)
What happens to the brain during the transition from sporadic to chronic binge drinking? This is the question explored by a joint research project of the Universities of Mannheim-Heidelberg and Cologne
The team tested this hypothesis through studies in Drosophila and mouse models and found that ethanol induced changes in two areas: mitochondrial dynamics and balance between neuronal synapses
It is well known that morphological remodeling of neurons underlies learning and memory
Henrike Scholz said: "It is noteworthy that the cellular processes responsible for this complex rewarding behavior are conserved across species, suggesting that humans play a similar role
Both of these observed mechanisms could explain observations made in mice that a single experience of intoxication can increase both drinking and alcohol relapse
Johannes Knabbe, Jil Protzmann, Niklas Schneider, Michael Berger, Dominik Dannehl, Shoupeng Wei, Christopher Strahle, Michèle Tegtmeier, Astha Jaiswal, Hongwei Zheng, Marcus Krüger, Karl Rohr, Rainer Spanagel, Ainhoa Bilbao, Maren Engelhardt, Henrike Scholz, Sidney B.
