PNAS: Discover switches associated with inflammation caused by overeating may help develop new treatments for metabolic diseases such as obesity. 

July 11, 2020 // In a recent study published in the international journal PNAS, scientists from Yale University and others identified a particular molecule that plays a key role in the body's inflammatory response to overeating, which can cause obesity, diabetes and other metabolic diseases, and is expected to be a potential therapeutic target to help control the body's inflammatory and metabolic diseasesPicture Source: CC0 Public Domain When a person eats too much, the body stores too many calories in fat tissue in the form of fat, as calorie intake continues to increase, the fat tissue will become inflammatory and release fatty acids into other tissues, including liver and muscle tissue, which is very dangerous and very likely to cause metabolic diseases such as diabetesnow researchers realize that overeating can lead to inflammation and metabolic diseases, but so far, they don't know how immune cells such as macrophages, which respond to excessive calorie intake, promote inflammation, and in this study, researchers have found a signaling pathway called O-GicNAc, which is activated when a person eats overeating, and which also directs cells to limit inflammationinflammation is triggered when the body's immune system responds to damage or threats, including increased blood flow, capillary dilation and white blood cell inflow, researcher Yang saidin particular, the researchers found that the enzyme-OGT (O-GicNAc transferase) that activates the O-GicNAc signal may activate the body's pro-inflammatory response by opening or closing a special signaling pathway in macrophagesmacrophage is both a "good helper" and a "bad role", when the body overeats it will play the role of bad person, secreting a large number of inflammatory factors, and in other cases, it plays the role of good people, play the body's anti-inflammatory effect;, the researchers in the study also revealed the rental of glutamine and glucosamine, two nutritional supplements recommended by clinicians to treat arthritis, although the researchers know that these supplements promote O-GicNAc signals and reduce inflammation, but they do not know the specific mechanism of actionthe study, the researchers also revealed the molecular mechanisms of glutamine and glucosamine to suppress inflammation in the bodyOriginal origins from the: Yunfan Yang, Xiruo Li, Harding HLuan, et alOGT suppresses S6K1-mediated macrophage and saline saita, the national academy of proceedings (2020)DOI: 10.1073/pnas.1916121117.