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A few years ago, Professor Kathrin de la Rosa and her colleagues made an unusual discovery in the laboratory of Swiss immunologist Antonio Lanzavecchia
However, the immune systems of people infected with malaria apparently fought back
This strategy is common
The initial discovery raised many questions for de la Rosa
In a study published in the journal, de la Rosa and her team have provided preliminary answers to these questions
Furthermore, the authors believe that the foreign material is only found in one specific region of the antibody, the heavy chain segment of the Y-shaped protein
In their work, the research team developed their own technique to study antibody transcription -- that is, the RNA matrix read during protein production -- using high-throughput analysis
The goal is to make a cellular vaccine
"Until now, it has been assumed that antibody diversity is only due to mutations in antibody genes," explains de la Rosa
"During the COVID-19 pandemic, millions of people around the world have learned and experienced first-hand the importance of antibodies as they protect us from pathogens such as SARS-CoV-2
article title
Mikhail Lebedin et al.