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    Home > Biochemistry News > Biotechnology News > PNAS: Different classes of genomic insertions contribute to human antibody diversity

    PNAS: Different classes of genomic insertions contribute to human antibody diversity

    • Last Update: 2022-09-08
    • Source: Internet
    • Author: User
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    A few years ago, Professor Kathrin de la Rosa and her colleagues made an unusual discovery in the laboratory of Swiss immunologist Antonio Lanzavecchia


    However, the immune systems of people infected with malaria apparently fought back


    This strategy is common

    The initial discovery raised many questions for de la Rosa


    In a study published in the journal, de la Rosa and her team have provided preliminary answers to these questions


    Furthermore, the authors believe that the foreign material is only found in one specific region of the antibody, the heavy chain segment of the Y-shaped protein


    In their work, the research team developed their own technique to study antibody transcription -- that is, the RNA matrix read during protein production -- using high-throughput analysis


    The goal is to make a cellular vaccine

    "Until now, it has been assumed that antibody diversity is only due to mutations in antibody genes," explains de la Rosa


    "During the COVID-19 pandemic, millions of people around the world have learned and experienced first-hand the importance of antibodies as they protect us from pathogens such as SARS-CoV-2


    article title

    Mikhail Lebedin et al.



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