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They take blood samples, and before long, researchers can find out if a person is developing lupus erythematosus, or signs that they are already sick
.
This revolutionary technology could be an important tool for diagnosing more autoimmune diseases
Autoimmune diseases — diseases in which our own immune system damages the body — are on the rise, but we know very little about what causes them
.
Researchers are now one step closer to finding the answer
.
With the help of a new technique, researchers at Aarhus University have succeeded in identifying particles in the blood that determine the development of autoimmune diseases
particles in nanometers
"We could see an increased proportion of large particles in the patient's blood
.
Because of their size, they are distributed at the edges of the blood vessels, where they may enter the vessel wall and create inflammation," said a postdoc at the Department of Biomedicine at Aarhus University.
Kristian Juul Madsen explained
He is the lead author of a recently published study describing how researchers took advantage of a new technology that allowed them to track specific protein particles in a patient's blood sample and measure their size in nanometers
.
By doing so, the size and structure of the particles are critical to the development of the disease
Postdoc Kristian Juul Madsen (right) explains: "We could follow this process on a screen, which led us to discover that lupus patients have higher concentrations of very large particles in their blood
.
" Credit: Simon Byrial Fischel
"We linked protein particles to small metal particles that fluoresced strongly when illuminated by a laser
.
We could follow this process on a screen, which allowed us to find higher concentrations of larger particles in lupus patients," Kristian Juul Madsen
"This technology can identify a rare but critical disease in lupus patients
.
We believe that in order to avoid disease, you have to stay below a critical level
Early diagnosis of the disease is important because treatment can reduce symptoms and prevent organ damage
.
So in a clinical setting, it would also be very interesting for researchers to be able to take a blood sample and know after 5 minutes whether a patient is developing lupus erythematosus or is already sick
blood sample collected
The study of lupus patients was established in collaboration with the Department of Rheumatology at Aarhus University Hospital, where Anne Margrethe Troldborg, Assistant Professor at the Department of Biomedicine, brought together one of the most extensive lupus cohorts in Denmark
.
Her work on lupus patients gave researchers a head start because blood samples from patients and controls had already been collected -- work that would otherwise have taken years
.
The new technology is expected to become a clinical diagnostic tool at Aarhus University Hospital within 5-10 years
.
patented technology
The discovery of the disease-causing particles has led to a better understanding of why the disease occurs
.
In the long run, this will help prevent the development of lupus and improve researchers' understanding of genetic and other factors
.
Together, Kristian Juul Madsen and Prof.
Thomas Vorup-Jensen have patented the technology, which they call NIP-Q (Nanoscale Immunoreactive Protein Quantification)
.
At first, the patent only applied to the analysis of proteins in lupus patients, but the research team hopes the technology can also be used to detect other inflammatory diseases, such as rheumatoid arthritis
.
"In the research community, the focus has been on how inflammatory diseases lead to the release of DNA in the blood, and how this process can activate the immune system to a certain extent
.
But by sizing blood components, we have gained entirely new insights
.
See It will be interesting to see how we can use the new technology to discover the correlation between particle size and immune response,
" says Thomas Vorup-Jensen
.
Making an accurate diagnosis and monitoring the development of an autoimmune disease is often difficult for doctors, he explained
.
This makes it difficult to make decisions about drugs and measure their effects
.
"However, the cost of autoimmune diseases continues to increase, both due to their increased incidence and the development of expensive new drugs
.
Therefore, better measurement methods are needed to enable a meaningful impact on health care and health economics.
treat in a responsible manner," said Thomas Vorup-Jensen
.
Original search:
“Characterization of DNA–protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus” by Kristian Juul-Madsen, Anne Troldborg, Thomas R.
Wittenborn, Mads G.
Axelsen, Huaying Zhao, Lasse H.
Klausen, Stefanie Luecke, Søren R.
Paludan, Kristian Stengaard-Pedersen, Mingdong Dong, Holger J.
Møller, Steffen Thiel, Henrik Jensen, Peter Schuck, Duncan S.
Sutherland, Søren E.
Degn and Thomas Vorup-Jensen, 27 July 2021, Proceedings of the National Academy of Sciences .
DOI: 10.
1073/pnas.
2106647118
