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A researcher at the University of Missouri School of Medicine has discovered an enzyme that plays a key role in the ability of cancer cells to resist drug treatments
Immunomodulatory drugs such as thalidomide, lenalidomide and premalidomide have improved the treatment of patients with multiple myeloma and other blood cancers
Dr.
Nguyen said: "This USP15 protein protects cancer cells from destruction by removing the ubiquitin tags placed on cells by immunomodulatory drugs
Nguyen believes that the USP15 test for patients with multiple myeloma will help determine whether the patient will develop resistance to immunomodulatory drug therapy
Nguyen said: "This work can lead us to discover whether the combination of USP15 inhibitors and other drugs will be more effective in treating cancer