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SEPTEMBER 24, 2020 /--- According to a new study published this week in THE journal PLOS Medicine by Xanthe Matthijssen of Leiden University Medical Center in the Netherlands, while the activity of most rheumatoid arthritis (RA) patients improves over time, long-term results only improve RA patients' own antibodies.
findings suggest that RA with autoantibodies is two distinct subsypes.
rheumatoid arthritis is the most common type of autoimmune arthritis caused by the immune system attacking healthy cells in the inner walls of the joints.
past decade, researchers have found differences in autoantibodies in the blood of RA patients.
the new study, researchers studied 1,285 RA patients between 1993 and 2016.
collect annual data on patient symptoms, treatment, autoantibodies, disability and mortality.
(Photo source: www.pixabay.com) found a total of 823 autoantibodies-positive RA and 462 autoantibody-negative RA.
between 2006 and 2010, targeted treatment strategies developed for autoantibody-positive RA patients contributed to a sustained increase in drug-free remission rates.
, only for patients who are self-antibody-positive, the rate of mortality and disability can be effectively reduced by adjusting treatment targets.
" in patients with RA without autoantibodies, the independentness between improved disease activity and improved long-term outcomes suggests that the underlying pathogenesis of autoantibodies is different.
" "We recommend that RA be formally classified as type 1 with autoantibodies and type 2 without autoantibodies, in the hope that it will lead to stratization of autoantibodies-positive and autoantibody-negative RA.
Bioon.com Source: Is rheumatoid arthrhritis two different diseases?Source:Matthijssen XME, Niemantsverdriet E, Huizinga TWJ, van der Helm-van Mil AHM (2020) Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands. PLoS Med 17 (9): e1003296. doi.org/10.1371/journal.pmed.1003296.
