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Picture: Fat Fly-a thin model of human obesity
Source: Neha Agrawal and Andrea H.
On November 4, Sadaf Farooqi and Andrea Brand of the University of Cambridge, UK, and their colleagues published a new study in PLOS Biology (PLOS Biology).
Identifying the genes that cause obesity has always been a challenge for several reasons, including weight, which is an organism-level feature that is not well modeled in cell culture
In contrast, experiments on fruit flies are fast and relatively inexpensive, which means that the effects of many genes can be screened at the same time
In order to find obesity genes, the author started with a large number of gene sequences of early severely obese patients, including many close relatives.
After reducing the activity of four genes, triacylglycerides increased significantly, one of which was called dachsous, which was not previously associated with human obesity
In humans, the authors found that rare gene variants FAT4 and TAOK2, which encode two other members of the Hippo pathway, are also associated with obesity, although not in every database
Dr.
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