PLoS Biol: Yap inhibits T-cell function and leaching in tumor microenvironment
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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A major challenge in cancer immunotherapy is to maintain the activation and recruitment of T cells in immunosuppressive solid tumorsHere, we report that the level of the Hippo path effect factor Yes-related protein (Yap) is induced sharply after cluster activation of the differentiation 4 (CD4) positive and differentiated 8 (CD8) positive T cells, and that Yap acts as an inhibitor of immunosuppressive factor and effect factor differentiationThe absence of Yap inT cells leads to activation, differentiation, and enhanced function of T-cells, which improves the ability to convert T-cells into T-cells to immerse and compress tumorsThe gene expression analysis of tumor-immersed T-cells after Yap's absence shows that Yap, as a mediate agent for global T-cell response in tumor microenvironment, is a negative regulatory factor for T-cell tumor immersion and patient survival in different human cancersoverall, our results suggest that Yap plays a key role in T-cell biology and suggest that Yap inhibition can improve T-cell response in cancer
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