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Phase 1/2 clinical trial of nitric oxide synthase inhibitor L-NMMA and taxane in the treatment of chemotherapy-resistant triple-negative breast cancer

 Last Update: 2021-12-27
 Source: Internet
 Author: User

Successful combination

A phase 1/2 clinical trial tested the effects of inducible nitric oxide synthase inhibitor (L-NMMA) combined with taxane in the treatment of refractory locally advanced breast cancer (LABC) and metastatic triple-negative breast cancer (TNBC) Curative effect

The total effective rate was 45.

Previous studies using in vivo models have shown that the use of pan-NOS inhibitor NG-methyl can inhibit the iNOS signaling pathway-I-Arginine (L-NMMA) reduces tumor growth and improves survival in TNBC patients

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