Pharmaceutical grade Poloxamer 188 in various industries

Pharmaceutical grade Poloxamer 188 in various industries 1, as an emulsifier and stabilizer: Poloxamer188 (Pluronic F68) as a water-in-oil emulsifier is one
of the very few synthetic emulsifiers used in intravenous emulsions.

Dosage 0.
1% to 5%.

The emulsion prepared with this product has fewer milk particles, generally less than 1 μm, and the absorption rate is high
.

Physically stable, it can withstand hot pressure sterilization and low temperature freezing
.

Application examples: Fat emulsion for injection, Lipomul's prescription: cottonseed oil 150g, soy phospholipids 12g, Pluronic F68 3g, glucose 40g, water for injection added to 100ml
.

2 As a solubilizer: this product can increase the surface solubility of a variety of drugs due to the formation of glue mass of surfactant, such as salicylic acid, tranquility, indomethacin, drip and so on
.

Taking salicylic acid as an example, salicylic acid can be solubilized in two Pluricoids Pluric L65 and Pluric F68, each mole of Pluric L65 can increase the soluble salicylic acid 1.
3 mol, and per mole of Pluric F68 can increase the soluble salicylic acid 0.
93 mol, indicating that salicylic acid is stable in different concentrations
of Pluric acid.

Solubility of salicylic acid per minute in Pruriconic (mg/ml×10,000).


The solubility of salicylic acid in F68 gradually increases with the increase of the concentration of the active agent, but in L65, the solubility increases rapidly to the maximum with the increase of concentration, but then gradually decreases
.

3 As an absorption promoter: on the one hand, because this product slows down the intestinal peristalsis, the drug stay time in the gastrointestinal tract increases, and the absorption increases, thereby improving the bioavailability of oral preparations, on the other hand, this product has good compatibility with the skin, increases skin permeability, and can promote the absorption
of topical agents.

4 As a sustained release material: a solid product with a large molecular weight, used as a binder, coating material, etc.
to prepare tablets, capsules, gels, etc.
, to achieve the purpose of sustained release and controlled release, and has now obtained a more satisfactory effect
.

Dosage 5% to 15%.


5 As a solid dispersant: Pluronic solid model products, can be used as a carrier of solid dispersions, such as phenylbutazone, griseofulvin, digitalis toxin and the solid dispersions prepared by this product, greatly improving the solubility of these drugs and promoting the absorption
of these drugs.

Dosage 2% to 10%.


6 As a cream, suppository matrix solid model of this product is not only soluble, can promote the absorption of drugs, as a matrix can also play a sustained release
.