-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Dr.
In a new UC Irvine-led study, researchers define how the circadian clock affects cell growth, metabolism and tumor progression
The study, "Circadian clock driver disrupts Apc loss of heterozygosity accelerates colorectal cancer," published today in Science Advances
In this study, researchers found that both genetically disrupted and environmentally disrupted circadian clocks contribute to mutations in the adenomatous polyposis Escherichia coli (APC) tumor suppressor, which is seen in the vast majority of human colorectal cancers (CRCs).
According to the National Institutes of Health, there has been an alarming rise in the incidence of early-onset colorectal cancer among young adults
APC mutations have also been implicated in the second hit of key oncogenic pathways, including Kras, Braf, p53 and Smad4, which drive the development of adenocarcinomas and together contribute to disease progression
Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer
