Oxidative stress interference is expected to be a new means of disease prevention

oxidation stress (OS) is the body in need of the removal of aging cells in the body, or when subjected to various harmful stimuli, the body's highly active molecules, such as reactive oxygen free radicals (ROS) and active nitrogen free radicals (RNS) produce too much, oxidation more than the removal of oxides, oxidation system and antioxidant system imbalance, resulting in tissue damageResearch in this field has been the focus of basic researchIn recent years, researchers in the United States have proposed new ideas for oxidative stress interference and made some new advances in the study of antioxidant therapyThe theory of oxidative stress window periodAmerican researchers based on a large number of research progress to put forward a new hypothesis - oxidative stress window period theoretical hypothesisThis theory holds that oxidative stress is an inevitable state in the body, and the longest interval for diseased injuries to the body is the period of oxidative stress windowInterventional interference during this time period, if the body can quickly reduce oxidative stress, can effectively prevent the occurrence of variousdiseasesWhen the body is in ahealthystate, the use of oxidative stress to clean up aging cells, clean up and/or control the mutated cells (e.
tumorcells), so that the body is in a harmonious and orderly state, at this time the role of oxidative stress is positive, endogenousIt can be said that oxidative stress is the most fundamental means of self-renewal and self-protection achieved by biological organism after long-term development and evolutionIf for some or more reason interfere with this order in the body, for example, when an exoplanet invades the body, the body's first reaction is to initiate the metabolism process of the heterogenous material, the body produces a large number of free radicals, elevated oxidative stress in the body is used to kill and remove the exogenous materialThis process generally causes the body to produce excessive free radicals and their by-products, and the time to control oxidative stress should not be longer than its window periodBecause excess free radicals will first cause further disorder in the body through mutated proteins and lipids, thus inducing metabolism, circulatory abnormalities, or by directly participating in the way of gene expression, or through the indirect participation of certain free radical siurating substances to change gene expression and cause the main mechanism abnormal This results in an imbalance of strong oxidants and antioxidants in the body, resulting in a significant increase in oxidative stress levels During the period of oxidative stress window, this change in the body is still in the quantitative change stage, that is, "sub-
healthy ", no organic lesions, more than the oxidative stress window period will appear organic lesions In other words, oxidative stress that cannot be recovered during the oxidative stress window eventually causes the body to become lesions It should be noted that the incubation period of oxidative stress and the incubation period of the disease is different The latter is the time interval of oxidative stress increased to disease the appearance of clinical manifestations, which are generally longer than the oxidative stress window period Oxidative stress interference sometimes, the use of drugs to treat some diseases, the effect is not obvious Further studies have shown that when these drugs are used, the levelof oxidative stress in the patient's body does not decrease, but increases For example, under the influence of most sugar-lowering drugs, the blood sugar level of diabetic sane patients is reduced, but the oxidative stress level often increases, causing further damage to the patient's body and eventually developing chronic complications of diabetes Even insulin does not improve oxidative stress in the patient In this respect, effective treatment should be to eradicate the underlying cause of disease generation while directly eliminating the appearance of disease, i.e the removal of the high oxidative stress state that causes the disease at the level of small molecules and even atoms The researchers found in the diabetes study that when the use of streptococcus injections to prepare diabetic mice, if the first injection of streptococcus, or within 40 hours of the first injection of streptococcus, Wistar rats increased oxidative stress, to give the rats enough thioic acid, after a week only average Thirty-five percent of rats became diabetic mice, and after 40 hours of increased oxidative stress in the first injection of streptococcus and rats, the rats were given no matter how much thioic acid, and the result was that after a week an average of 85 percent of rats became diabetic mice The results show that diseases caused by increased oxidative stress are preventable, but this preventable period is limited In other words, after the window period, it is time to enter the stage of treatment and delay, rather than prevention The oxidation stress interference method first determines whether the elevated oxidation stress is positive or toxic side effect, the area where oxidative stress increases, the particularity of the body that produces oxidative stress, the period of oxidative stress window, and so on, and then determines the appropriate method to interfere with a specific area, substance or organ Rapidly reduce their oxidative stress during the oxidative stress window period, and the matching of specific formulations and specific regions determines the effect of oxidative stress interference The characteristics of the formulation used in the oxidation stress interference method and the areas of the desired action should follow the principle of similarity, including material structure, electricality, acid alkalinity, ligation, etc., as evidenced by recent research results For example, trace element copper on certain groups it no longer plays the role of assisting in the capture of free radicals, but rather stimulates diabetics to produce excessive free radicals, especially in patients who have developed chronic complications of diabetes, the content of copper and iron trace elements in the body significantly increased, while excessive free radicals of copper trace elements are an important cause of lesions of diabetes the heart; It has also been identified as causing high blood sugar in diabetics, and for diabetics, too much calcium minerals also stimulates diabetics to produce excessive free radicals because they are prone to kidney stones, and there is no shortage of phosphorus in diabetics, which, when high levels of phosphorus in the body, stimulate diabetics to produce excessive free radicals, increasing the risk of coronary artery disease in diabetics For patients with high blood lipids, the oxidation of low-density proteins is the main cause of cardiovascular and vascular diseases, and in theory vitamin E should be able to effectively prevent the oxidation of low-density proteins, but this is not the case Unlike antioxidant connotations
oxidative stress interferes with what is now commonly said to be antioxidants The latter only provides the body with antioxidants to capture free radicals, but antioxidants do not necessarily reduce oxidative stress, sometimes increasing oxidative stress and causing further damage to the body Recent studies show that the antioxidant properties of a substance are closely related to the environment in which it is located, such as lipoic acid, which is a strong antioxidant for animal bodies in a state of illness and high oxidative stress, and for healthy , it is also an oxidant that can cause kidney damage; And, for many patients with diseases, the body will be rich in certain trace elements; flavonoids such as quercetin, which is often considered an antioxidant, need vitamin C or glutathione to have antioxidant function when they are present, which may also be the reason why quercetin has different short-term and long-term use effects; vitamin C, vitamin E and melatonin are the most accepted antioxidants, but when hydrogen peroxide is present, or when the concentration is low, C becomes an oxidant, and vitamin Serotoncosis is an oxidant Melatonin acts as an oxidant under certain conditions, causing the death of white blood cells These phenomena have been discovered in recent years, and their specific mechanisms of action, and even the determination of the transformation points of antioxidants/oxidants, have yet to be further studied Even more surprisingly, oxidants may also be one of the means to reduce oxidation stress, because oxidants also have the ability to reduce oxidation stress in certain situations, such as divalent iron complexes are the main substances that transmit molecular oxygen, when it is necessary to cut off the supply of oxygen to reduce oxidation stress in a particular area, the oxidants of divalent iron oxide as trivalent iron are used to reduce oxidation stress Reducing oxidative stress may also take other means, such as rapid discharge of free radicals, means and preparations to prevent or reduce the production of free radicals, catalyst formulations that promote free radicalself double polymerization and extinction, the ability to provide oxidants to alter the oxidation state of some metal ions so that they are not catalytic free radical spawning, or the ability to provide oxidants to alter the oxygen delivery of certain substances Good application prospects effective regulation of oxidative stress window period can prevent the occurrence of diseases Reducing oxidative stress can not only prevent and effectively treat diseases by reducing or even avoiding the structural modification of free radicals to specific genetic material DNA/RNA, protein molecules, lipids and other tissues important to life, preventing the destruction of these substances and effectively treat diseases, but also plays a good role in controlling the lesions (such as tumors cells) caused by mutated genetic material DNA/RNA Because these mutated tissue cells are different from normal cells, in theory, the body's immune system can automatically detect them and isolate them effectively If an effective way can be found to control the immune system at this location moderately so that it always the tumor cells in effective isolation, then there will be no tumor incidence at all, thus eliminating the disease of the body caused by the mutation of these substances The tumor is just a chronic disease The methods that stimulate the immune system to kill tumor cells often cause tumor cells to grow and spread The theory of oxidative stress window period and oxidative stress interference method, as well as the substance spent to reduce oxidative stress and the desired area of action should follow the principle of similarity, which may provide a solid theoretical basis for Chinese medicine to the world Because after thousands of years of development of Chinese medicine contains ingredients in the role of very much in line with this requirement (Zhu Zuohui)