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In Finland, about 550 women develop ovarian cancer each year
.
Ovarian cancer is difficult to treat and is often fatal, with 320 women dying from ovarian cancer each year in Finland
Cancer can only develop and develop when tumor cells are able to hide from the body's immune system
.
Cancer immunotherapy, a therapy that enhances the body's immune defenses against cancer, has emerged as a promising treatment in many types of tumors
Now, researchers at the University of Helsinki have revealed how tumor cells in ovarian cancer interact with the immune system
.
Using a new imaging technique, researchers have identified more than 110,000 individual cells from clinical ovarian cancer samples
"With the help of this revolutionary imaging technique and advanced data analysis, we were able to study individual tumor cells, their functional properties and interactions with unprecedented precision," says Associate Professor Anniina Färkkilä, corresponding author of the study
.
Tumor genes trick the immune system
"By directly studying individual cells in a tissue, we have shown how cancer cells hide in different ways depending on specific genetic mutations
.
We found that the body's immune system is more effective against tumors with mutations in the BRCA1/2 genes
BRCA1/2 mutations occur in approximately 20% of poorly differentiated serous carcinomas, the most common form of ovarian cancer
.
Killer T cells tightly protect aggressive tumor cells, especially in tumors with BRCA1/2 mutations, which is why these patients have a significantly better prognosis
"By increasing our understanding of how tumor genes trick the immune system, we will be able to develop more effective ways to activate the body's own immune defenses to kill cancer cells," Inga-Maria said
Study results will facilitate customization of precision treatment
The results of this study confirm the importance of the interaction between tumor and immune cells in identifying new and more effective treatments and choosing the right treatment for each patient
This discovery will allow us to develop precise immune and combination therapies that may even potentially cure ovarian cancer in the future
The research was published in the respected journal Nature Communications
Magazine
Nature Communications
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
