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news
newsThis year's Nobel Prize in Chemistry was awarded to Benjamin List of the Planck Institute and Professor David MacMillan of Princeton University for their contributions to the invention of asymmetric synthetic organic catalysts
.
Unlike traditional transition metal and enzyme catalysts, the organic asymmetric catalyst invented by the two scientists is simple in structure, easy to operate, and can catalyze common organic reactions
Drug source analysis
Drug source analysisChiral molecules are composed of two so-called enantiomers with almost identical properties.
Only in an asymmetric environment can these two enantiomers have different properties
.
There is only one enantiomer for all chiral molecules in the process of life, which is a phenomenon that is still a mystery until now
The more realistic problem is that if chiral biological macromolecules have only one enantiomer, then chiral drugs that regulate biological macromolecules usually need only one enantiomer
.
The other enantiomer is either less active, cadaveric meal in a racemic mixture, or helps produce toxicity, such as thalidomide
Unlike the earliest chirality source problem on earth, asymmetric synthesis because pure enantiomers already exist in nature, so it only needs to be able to transfer these existing chiral information to the product through a chemical reaction
.
If the substrate is already a pure enantiomer, the stereoselectivity of the newly generated chiral center in the same molecule is easier to control
In recent years, the Nobel Prize in Chemistry has rarely been issued to real chemists, and this year's award-winning work can be regarded as hard-core organic chemistry, so many chemists feel overwhelmed
.
This work is undoubtedly an important invention of organic chemistry.
