One picture to understand the similarities and differences between different "biological agents"

Biologics are not good or bad, only suitable and unsuitable, so it is difficult to distinguish between "good" and "bad

At present, the most commonly used biological agents in clinical can be divided into two categories, namely interleukin-17A inhibitors and tumor necrosis factor antagonists.

Biologics are not good or bad, only suitable and unsuitable, so it is difficult to distinguish between "good" and "bad

At present, the most commonly used biological agents in clinical can be divided into two categories, namely interleukin-17A inhibitors and tumor necrosis factor antagonists.

Which patients can use biologics?

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Which types of ankylosing spondylitis patients need combination therapy?

If the patient has had difficulty in hunchback, squatting, bending over, or even paralyzed in bed, at this time, no matter which biological agent is used, it will not help, because the deep inflammation of the patient's joint cavity has accumulated, and adhesions and fusions have been formed.

Which types of ankylosing spondylitis patients are not suitable for biologics

① There is an active infection

② Those with combined or hepatitis B infection history without standard treatment or active

③ History of Pneumocystis carinii pneumonia

④ Combined with moderate to severe congestive heart failure

⑤ Patients with malignant tumor

⑥ Demyelinating lesions of the nervous system

⑦Allergies

⑧It is not recommended to use during pregnancy, pregnancy and breastfeeding

Be wary of side effects with biologics!

① Infection: such as respiratory tract infection, urinary tract infection, tuberculosis, pneumonia, etc.

②Tumor: Excessive immunosuppression increases the risk of tumorigenesis;

③ Injection site reactions: redness, swelling, rash,

Pre- and post-use screening programs for biologics

In order to ensure the safety of biological preparations, blood routine tests, erythrocyte sedimentation rate, CPR, liver and kidney function, viral hepatitis series, TSPOT, chest X-ray and other tests are required before use to exclude tumors, active infections, tuberculosis, hepatitis,

How long to stop using biologics

The use of biological agents generally does not have a course of treatment, but some doctors will give patients a 3-6 month course of treatment because of the cost and risk of side effects, so as to control the acute stage disease into a stable stage, but it does not mean that it will not be stopped after stopping.

In summary:

The selection and applicability of biological agents should be determined according to multiple factors such as the patient's condition, physical condition, and economic conditions.