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When visiting a rheumatology specialist
Doctors often ask to test for autoantibodies
Why do this check?
What are the clinical implications?
How should the test results be interpreted ?
Today we are going to talk about those things about autoantibodies
When visiting a rheumatology specialist
When visiting a rheumatology specialistDoctors often ask to test for autoantibodies
Doctors often ask to test for autoantibodiesWhy do this check?
Why do this check?What are the clinical implications?
What are the clinical implications?How should the test results be interpreted ?
How should the test results be interpreted ? interpretToday we are going to talk about those things about autoantibodies
Today we are going to talk about those things about autoantibodies
What are autoantibodies?
What are autoantibodies? Under normal circumstances, antibodies are an important component of building the body's immune barrier.However, sometimes, for some reasons, the body will produce some mutated antibodies, these antibodies are like the rebels of the immune system.
It is only when the antibody concentration exceeds a certain value that the body becomes sick
When the concentration of autoantibodies is lower than a certain level, it will not have obvious effects on the body , and no special treatment is required
When the concentration of autoantibodies is lower than a certain level, it will not have obvious effects on the body , and no special treatment is required
When the concentration of autoantibodies is lower than a certain level, it will not have a significant impact on the body.
It is only when the antibody concentration exceeds a certain value that the body becomes sick
It is only when the antibody concentration exceeds a certain value that the body becomes sick
What are antinuclear antibodies? Anti-nuclear antibody is also called anti-nucleic acid antigen antibody
How to interpret antinuclear antibodies?
Step 1: Focus on antibody titers first
The first step: first focus on the antibody titer First step: first focus on the antibody titer Common antinuclear antibody titers include 1:100, 1:320, 1:1000, and 1:3200(2) Healthy people and healthy people : Studies have pointed out that the positive rate of ANA in healthy people is as high as 11.
(3) Other diseases Other diseases :
-
Pulmonary diseases : such as idiopathic pulmonary fibrosis, idiopathic pulmonary hypertension;
-
Chronic infections : such as parasites, Mycobacterium tuberculosis infection, etc.
-
Liver disease : such as active hepatitis, alcoholic liver disease, etc.
-
Blood system diseases : such as leukemia , myeloma, etc.
-
Other systemic diseases : such as after organ transplantation, end-stage renal disease, type I diabetes
Pulmonary diseases : such as idiopathic pulmonary fibrosis, idiopathic pulmonary hypertension;
Pulmonary diseases : such as idiopathic pulmonary fibrosis, idiopathic pulmonary hypertension;
Pulmonary diseases : such as idiopathic pulmonary fibrosis, idiopathic pulmonary hypertension;Chronic infections : such as parasites, Mycobacterium tuberculosis infection, etc.
Chronic infections : such as parasites, Mycobacterium tuberculosis infection, etc.
;
;
Liver disease : such as active hepatitis, alcoholic liver disease, etc.
;
Liver disease : such as active hepatitis, alcoholic liver disease, etc.
;
;
Blood system diseases : such as leukemia , myeloma, etc.
;
Blood system diseases : such as leukemia , myeloma, etc.
;
; leukemia
Other systemic diseases : such as after organ transplantation, end-stage renal disease, type I diabetes
, etc.
Other systemic diseases : such as after organ transplantation, end-stage renal disease, type I diabetes
, etc.
, etc.
diabetes
As shown in the figure above, the patient's antinuclear antibody titer is 1:1000.
Even if there are no abnormal antibodies in the latter, autoimmune diseases are considered, but which autoimmune diseases are specific, it is necessary to combine the abnormal antibodies and clinical manifestations to comprehensively judge
.
Clinical significance of antinuclear antibody profiles
Clinical Significance of Antinuclear Antibody Spectrum Clinical Significance of Antinuclear Antibody ProfileSome antinuclear antibodies have certain specificity, and the corresponding autoimmune disease should be highly suspected when the antibody is positive.
Summarize
summary summaryThe above content is only a small part of autoantibodies and cannot cover all
.
With the development of the discipline, the understanding of autoantibodies and autoimmune diseases is getting deeper and deeper
.
Although autoantibodies are crucial to the diagnosis of autoimmune-related diseases , the results of autoantibody tests cannot independently diagnose the disease.
Clinically, it is necessary to combine clinical manifestations, other tests, and test results to make a comprehensive judgment
.
Therefore, when the physical examination finds abnormal autoantibodies, it is recommended that you seek a diagnosis from a rheumatology immunologist as soon as possible
.
references
References ReferencesProfessional Committee on Autoantibody Detection of Rheumatology and Immunology Branch of Chinese Medical Doctor Association.
Expert consensus on clinical application of antinuclear antibody detection [J].
Chinese Journal of Laboratory Medicine, 2018, 41(4): 275-280.
Expert consensus on clinical application of antinuclear antibody detection [J].
Chinese Journal of Laboratory Medicine, 2018, 41(4): 275-280 .
