One arrow, three sculptures! New drugs can inhibit the growth, drug resistance and metastasis of pancreatic cancer!

September 27, 2018 / BIOON / - a newly developed drug can prevent the growth and metastasis of the most common pancreatic cancer in experimental mice, according to a new study led by cedars Sinai Medical Center The study, published in the journal Gastroenterology, also found that metavert may prevent patients from developing resistance to existing chemotherapy drugs for pancreatic cancer Photo source: Gastroenterology "this is an exciting finding that may help improve the survival rate of patients with pancreatic cancer." Dr mouad edderkaoui, assistant professor of pharmaceutical and biomedical sciences, Samuel Oschin Institute of comprehensive cancer, West dakina medical center, said he was the lead author of the study "If we can verify these results in humans, then we have drugs that can significantly prolong the survival of patients with pancreatic ductal adenocarcinoma (PDAC), which is a very difficult cancer to treat." Pancreatic cancer is the third leading cause of cancer-related death in the United States It is estimated that 55000 people will be diagnosed with PDAC in the United States this year, and 44000 will die from PDAC At present, the five-year survival of pancreatic cancer is only 7% About 95% of pancreatic cancer patients are PDAC, which comes from the cells in the inner wall of pancreatic tubules Professor Stephen J pandol, co-author of the study and director of the Institute of basic and translational pancreas research at cedars Sinai Medical Center, said that PDAC is difficult to treat because cancer cells promote normal cells (astrocytes) in the pancreas to produce pancreatic scar tissue, which makes it difficult for chemotherapy drugs and blood to enter the pancreas The interaction between tumor cells and astrocytes will also create a microenvironment that can stimulate local tumor growth and transfer to other parts of the body In addition, the activity of some enzymes in the pancreas will also increase, thus enhancing the resistance of the tumor to treatment "I've seen a lot of patients respond to treatment for a short period of time, but then the tumors grow like crazy because they get smarter and they can make chemotherapy drugs ineffective." Pandol said "Metavert is one of these characteristics that targets tumors." Over the past four years, researchers have designed and synthesized new compounds that inhibit the activity of cancer cells They found that metavert can inhibit the chemoresistance of tumors, but also significantly enhance the efficacy of radiotherapy and two commonly used chemotherapy drugs In a mouse study, metavert increased mouse survival by 50% Researchers are now working on further development to test in humans Reference: mouad edderkaoui et al, an inhibitor of gsk3b and HDACs kills pancreatic cancer cells and slows pancreatic tumor growth and metastasis in mice, gastroentrogy (2018) Doi: 10.1053/j.gastro.2018.08.028