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    Home > Biochemistry News > Biotechnology News > Oncolytic virus CG0070 achieves 100% CR in high-risk bladder cancer patients Domestic Lepu Biotech has obtained clinical approval

    Oncolytic virus CG0070 achieves 100% CR in high-risk bladder cancer patients Domestic Lepu Biotech has obtained clinical approval

    • Last Update: 2022-02-26
    • Source: Internet
    • Author: User
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    Recently (November 13, 2021), CG Oncology disclosed the very eye-catching Phase II clinical trial data of its oncolytic virus drug CG0070 combined with K drug


    NMIBC urgently needs new treatments

    NMIBC urgently needs new treatments

    Bladder cancer is one of the common malignant tumors of the urinary system (NMIBC accounts for 70% to 80% of bladder cancers), and has the characteristics of easy invasion, recurrence, drug resistance, and multicenter


    At present, the treatment methods for NMIBC are very limited.


    Single-agent CR was significantly better than K-drug

    Single-agent CR was significantly better than K-drug

    CG0070 is an engineered adenovirus type 5 (Ad5) oncolytic virus drug developed by CG Oncology


    Previously, CG Oncology has disclosed the dazzling data of the Phase II clinical trial (BOND II) of the single drug of CG0070


    The CR rate of combined K drug is as high as 100%

    The CR rate of combined K drug is as high as 100%

    In addition to single drugs, CG0070 is also trying to use the combined effect of immune checkpoint inhibitors


    The clinical data of CG0070 combined with K drug released this time are also amazing


    CG-007 has demonstrated extraordinary efficacy in high-risk NMIBC patients who do not respond to BCG, whether it is a single drug or a combination drug.


    Domestic Lepu Bio has the authorization to develop, manufacture and commercialize this product in China


    Lepu Bio is also currently planning to initiate a clinical trial of CG0070 in combination with its core product HX008 for patients with advanced NMIBC (Putlimumab (HX008) is an anti-PD-1 monoclonal antibody product of Lepu Bio.


    Summarize

    Summarize

    As an important means in the current field of tumor immunotherapy, the therapeutic potential of oncolytic virus drugs in various diseases such as malignant tumors has attracted more and more attention from scientific research and industrial circles


    Thanks to the advancement of genetic engineering technology, the development of oncolytic viruses in China has become increasingly active.


    (Source: Biopharmaceutical Editor)

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