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Oncogene: DCAF12 is a novel antagonist of anti-apoptotic protein IAPs

 Last Update: 2022-05-14
 Source: Internet
 Author: User

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Associate Researcher Wang Chenji of Fudan University and Professor Li Liang of Zibo Central Hospital jointly published a paper titled " DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of " Oncogene Magazine on April 22 , 2022 .

Apoptosis or programmed cell death is an evolutionarily conserved process that is required for normal development, homeostasis and integrity of multicellular organisms

DCAF12 is a substrate-recognition subunit of the Cullin 4 ( CUL4 ) E3 ubiquitin ligase complex

Molecular mechanism of DCAF12- dependent regulation of apoptosis by IAPs

Jiao Dongyue and Chen Yingji, doctoral students of the School of Life Sciences of Fudan University, are the co-first authors of the paper, and Associate Researcher Wang Chenji and Professor Li Liang of Zibo Central Hospital are the co-corresponding authors of the paper

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