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October 22, 2021: He Xiangwei's laboratory published a long article in PNAS revealing unstable genetic traits and genome diversity mediated by reversible genetic mutations

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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He Xiangwei hospital laboratory and Peking University Center for Quantitative Biology, Lucas Carey laboratory cooperation in the "American Academy of Sciences" ( PNAS ) 20 21 Nian Yue 10 22 research papers published daily online "A Rapidly Reversible mutation.

This work first discovered in fission yeast S.

This work provides direct experimental evidence for the hypothesis that "single-copy to two-copy MTD mutations may be the origin of multiple copies of tandem repeats that already exist in the genome" (see references); at the same time, it reveals the hidden hidden in the cell population.

Dr.

MTD mutation pattern diagram (top);

Fragment with miniature homology arms in fission yeast, distribution map of MTD mutations captured by prediction and sequencing on chromosome 1 (bottom)

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