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NSR (IF=23) Chinese Academy of Sciences Shi Jianlin's team discovered the immune mechanism of using nanomedicine to treat colorectal cancer

 Last Update: 2022-09-08
 Source: Internet
 Author: User

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Tumor associated bacteria (TAB) play a crucial role in regulating the tumor microenvironment, however inactivation of the associated bacteria by chemotherapy and radiation therapy greatly reduces the therapeutic effect and, more importantly, leads to Significant immunosuppression

On August 29, 2022, Shi Jianlin and Hu Ping of the Shanghai Institute of Ceramics, Chinese Academy of Sciences jointly published a research paper entitled "Nanocatalytic bacteria disintegration reverses immunosuppression of colorectal cancer" in the journal National Science Review (IF=23).

In this study, a monodisperse superparamagnetic nanocatalytic drug modified by arginyl-glycyl-aspartic acid (RGD) and (3-carboxypropyl) triphenylphosphonium bromide (TPP) was synthesized, And named as MNP-RGD-TPP (MRT), it is characterized by selective accumulation at TAB through electrostatic affinity, enabling efficient decomposition of TAB through nanocatalytic Fenton reaction at high temperature induced by alternating magnetic field (AMF), which is generated in situ.

Currently, a growing body of new evidence supports the fundamental role of the microbiome in cancer development and treatment

—END—The content is [iNature]

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