NRR: inhibitory effect of hypothalamic peptides on GnRH neurons
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Last Update: 2013-07-19
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Source: Internet
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Author: User
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In the last 10 years, people have a further understanding of the hypothalamic pituitary gonadal axis Two new hypothalamic arginine phenylalanine amide related peptide kisspeptin and gonadotropin inhibiting hormone have been found These substances can regulate the reproductive axis Kisspeptins is the most effective activator of the hypothalamus pituitary gonadal axis Kisspeptin and its receptor GPR54 are expressed in GnRH neurons and regulate their functions, which can promote the release of GnRH and the secretion of luteinizing hormone in early adolescence Kisspeptin / GPR54 system is very important for regulating sexual maturation and germ cell development Haluk, School of medicine, University of firat, Turkey Professor kelestimur's research team took GT1-7 cell line expressing gonadotropin releasing hormone as a model It was found that the gonadotropin inhibiting hormone or arginine phenylalanine amide related peptide 1 inhibited the activation of gonadotropin releasing hormone neurons activated by kisspeptins, and the inhibition did not need to reduce [Ca2 +] i 。 It is suggested that arginine phenylalanine amide related peptide 3,1 is involved in the regulation of hypothalamic pituitary gonadal axis.
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