 Home > Active Ingredient News > Immunology News > NPJM: Metagenome analysis reveals the potential role of gut microbiota in the pathogenesis of gout

NPJM: Metagenome analysis reveals the potential role of gut microbiota in the pathogenesis of gout

 Last Update: 2021-10-19
 Source: Internet
 Author: User

Tags

metabolic changes

bond 9 samples

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Gout is a mainly involving inflammatory arthritic joints, and is considered to be high blood pressure heart vascular disease risk factors
.

Gout is more common in men than women.

Heart blood vessels

The main cause of gout is known to be abnormal increase in uric acid and crystal crystallization of sodium urate (MSU)
.

In a healthy human body, there are two ways to excrete uric acid: the kidneys are responsible for the excretion of 70% of the uric acid, and the intestines are responsible for the excretion of the remaining 30%

Rheumatoid arthritis

This article conducted a large-scale microgenomics analysis on 307 gut microbiomes collected longitudinally from gout patients and healthy controls
.

Using the discovery and validation cohort, we tried to investigate the classification and functional characteristics of the gout gut microbiome, its relationship with gout-related clinical parameters (such as serum uric acid (SUA) and inflammation), its response to therapeutic interventions, and gout-related microbes The relationship between group characteristics and broader autoimmune and metabolic disorders

immunity

In summary, we determined the classification and functional characteristics of the gut microbiota related to gout, and based on our results, proposed a hypothetical model of how gut microbes affect the development of gout
.

The enrichment of Bacteroides and Provermectin may lead to changes in the biosynthesis of 6-acyl chain lipid A in Enterobacter gout, which will negatively affect host immune stimulation and endotoxin tolerance, resulting in 4- or 5 The biosynthesis of lipid A of each acyl chain is changed

Literature source: Chu Y, Sun S, Huang Y, Metagenomic analysis revealed the potential role of gut microbiome in gout.

Leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

High Purity 99% BPN14770 Zatolmilast 1606974-33-7 In Stock Fast Ship to USA

CAS No.: 1606974-33-7

Pharm Grade

$1-1.1/UNIT FOB

High quality Thymosin α1 Pure CAS 62304-98-7 Thymosin Alpha 1 Thymalfasin

CAS No.: 62304-98-7

Pharmacy Grade

$12-15/UNIT FOB

Top quantity Imiquimod CAS NO 99011-02-6 White crystalline powder 99% API

CAS No.: 99011-02-6

Pharmacy Grade

$1800-1850/KG FOB

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.