npj Precision Oncology: Amazing! The venom of small bees is of great use and can kill cancer cells 100% in in-body experiments.

Bee poison is a toxic liquid secreted by bees and horse bees and other bee venomous glands, its main component is composed of 26 amino acid residues of bee poison peptides, which is currently known to be one of the most anti-inflammatory substances, in anti-bacterial, anti-radiation, anti-viral and other aspects of significant efficacy.
a recent article in npj Precision Oncology laid the foundation for cancer treatment by revealing the molecular mechanisms and selectivity of biometrics in bee venom as anti-cancer drugs.
Specifically, researchers at the University of Western Australia's Medical Research Centre tested the anti-cancer properties of 312 bees and bumblebee venoms in breast cancer and found that bee venom can completely destroy cancer cell membranes within 60 minutes, and that specific concentrations of bee venom can induce 100% of cancer cell deaths with little impact on normal cells.
as early as 1950, Nature published its first reports on the effects of bee venom, which reduced the growth of tumors in plants.
it was only in the last two decades that there was a keen interest in the role of bee venom in different cancers.
At present, bee venom and bee venom peptides have shown anti-tumor effects in melanoma, non-small cell lung cancer, glioblastoma cells, leukemia, etc., although the effects of different bee poisons and bee venom peptides on breast cancer subsolution have not been studied.
In this trial, the researchers first tested bee venom and bee venom peptides on normal breast cancer cells as well as in cells of clinical subtypes of breast cancer, and found that both had significant effects, selectively and rapidly reducing the vitality of triple-negative breast cancer cells and breast cancer cells rich in human skin growth factor-2 (HER2, primary cancer gene) with little effect on normal cells.
, bee venom peptides are the most prominent bioactive anti-cancer compounds in venom.
, bumblebees have relatively low concentrations of bee venom peptides compared to bees.
To examine the mechanism and dynamics of cell death, the researchers treated triple-negative breast cancer cells for 18 and 24 hours with semi-inhibitory concentrations (IC50) of bee venom or bee venom, and quantified apoptosis deaths using cut caspase3 analysis, and found that individual bee venom peptides induced higher levels of apoptosis than bee venom.
Bee venom and bee venom peptides induced apoptosis and membrane destruction in subsequent experiments, the researchers also found that bee venom peptides can completely destroy cancer cell membranes within 60 minutes, in 20 minutes significantly reduce the growth of cancer cells and cell division necessary chemical information.
, bumblebee venom does not induce cell death even at very high concentrations.
further study of hive peptides that completely destroy cancer cell membranes within 60 minutes, the researchers found that bee toxins are integrated into the cell membrane through the charged sequence present at the C end, thereby inducing the remodeling and destruction of the membrane.
Duffy, lead author of the report and a professor at the University of Western Australia's Centre for Medical Research, said: "Under the influence of bee venom, the cancer signaling path is quickly shut down.
bee venom peptide regulates the signaling of breast cancer cells by inhibiting the activation of receptor skin growth factor receptors that are usually overexpressed in triple-negative breast cancer, and inhibits the activation of HER2, which is overexpressed in her2-rich breast cancer.
in addition, the study tested whether bee-toxic peptides could be used with existing chemotherapy drugs, and found that bee-toxic peptides could be used with small molecular compounds or chemotherapy drugs such as docetamol to treat highly invasive breast cancer.
combination of bee venom peptides and dorcie yew alcohol was very effective in reducing tumor growth in mice.
Professor Peter Klinken, chief scientist for Western Australia, who was not involved in the study, said: "This is an incredible surprise to find that bee venom, the main ingredient in bee poison, inhibits the growth of deadly breast cancer cells, particularly triple-negative breast cancer.
, this study demonstrates how bee-toxic peptides interfere with signaling path paths within breast cancer cells to reduce cell replication.
it provides another excellent example of how natural compounds can be used to treat human diseases.
, this study provides a reference for assisting in the development of new treatments for a variety of cancers associated with frequent drug resistance and poor prognosmation.
, however, the researchers note that the best delivery methods for bee peptides, as well as toxicity and maximum toned doses, need to be further evaluated before human trials can be conducted.
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